Ambisome
Ambisome is a liposomal formulation of Amphotericin B, a broad-spectrum antifungal antibiotic. The liposomal encapsulation alters the drug's pharmacokinetics, allowing for higher drug concentrations in infected tissues while significantly lowering the risk of renal toxicity compared to conventional amphotericin B deoxycholate.
Dosage by Body Weight
Dosage must be individualized based on body weight, severity of infection, and patient tolerance. Typically administered via intravenous infusion over 120 minutes. Ambisome must be reconstituted with Sterile Water for Injection and diluted only with 5% Dextrose Injection (D5W) to a concentration of 1.0 mg/mL to 2.0 mg/mL.
- Body Weight
- Below 5 kg
- Dose
- 1.5 mg to 25 mg daily (calculated at 3-5 mg/kg/day)
- Frequency
- Once daily
- Tracking Notes
- Administer via IV infusion. Strictly avoid saline solutions as they cause precipitation. Monitor serum creatinine and potassium daily.
- Body Weight
- 5-7 kg
- Dose
- 15 mg to 35 mg daily (calculated at 3-5 mg/kg/day)
- Frequency
- Once daily
- Tracking Notes
- Infuse over 120 minutes. Rate may be reduced to 60 minutes if well tolerated. Do not mix with other medications.
- Body Weight
- 8-10 kg
- Dose
- 24 mg to 50 mg daily (calculated at 3-5 mg/kg/day)
- Frequency
- Once daily
- Tracking Notes
- Flush existing IV line with D5W before and after infusion. Watch for acute infusion-related reactions.
- Body Weight
- 11-15 kg
- Dose
- 33 mg to 75 mg daily (calculated at 3-5 mg/kg/day)
- Frequency
- Once daily
- Tracking Notes
- An in-line membrane filter (pore size not less than 1.0 micron) may be used during administration.
- Body Weight
- 16-20 kg
- Dose
- 48 mg to 100 mg daily (calculated at 3-5 mg/kg/day)
- Frequency
- Once daily
- Tracking Notes
- Doses up to 6 mg/kg/day may be required for specific infections like Mucormycosis. Monitor liver function regularly.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 1.5 mg to 25 mg daily (calculated at 3-5 mg/kg/day) | Once daily | Administer via IV infusion. Strictly avoid saline solutions as they cause precipitation. Monitor serum creatinine and potassium daily. |
| 5-7 kg | 15 mg to 35 mg daily (calculated at 3-5 mg/kg/day) | Once daily | Infuse over 120 minutes. Rate may be reduced to 60 minutes if well tolerated. Do not mix with other medications. |
| 8-10 kg | 24 mg to 50 mg daily (calculated at 3-5 mg/kg/day) | Once daily | Flush existing IV line with D5W before and after infusion. Watch for acute infusion-related reactions. |
| 11-15 kg | 33 mg to 75 mg daily (calculated at 3-5 mg/kg/day) | Once daily | An in-line membrane filter (pore size not less than 1.0 micron) may be used during administration. |
| 16-20 kg | 48 mg to 100 mg daily (calculated at 3-5 mg/kg/day) | Once daily | Doses up to 6 mg/kg/day may be required for specific infections like Mucormycosis. Monitor liver function regularly. |
Formulation
Purpose
Used to treat serious, life-threatening systemic fungal infections, including cryptococcal meningitis in HIV-infected patients, visceral leishmaniasis, and empirical treatment for presumed fungal infection in febrile, neutropenic patients.
Generic Name
Amphotericin B LiposomalScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.