Alfarol
Alfarol contains Alfacalcidol, a synthetic analogue of Vitamin D3. It is rapidly converted in the liver to 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, which acts as a regulator of calcium and phosphate metabolism. It increases intestinal absorption of calcium and phosphate, promotes bone mineralization, and regulates parathyroid hormone levels.
Dosage by Body Weight
Dosage must be strictly individualized and adjusted according to biochemical responses (particularly serum calcium and phosphate levels) under close medical supervision.
- Body Weight
- Below 5 kg
- Dose
- 0.05 to 0.1 mcg/kg
- Frequency
- Once daily
- Tracking Notes
- Must be initiated and monitored strictly by a specialist. High risk of hypercalcemia in neonates.
- Body Weight
- 5-7 kg
- Dose
- 0.25 mcg
- Frequency
- Once daily
- Tracking Notes
- Dose titrated based on regular serum calcium determinations.
- Body Weight
- 8-10 kg
- Dose
- 0.4 to 0.5 mcg
- Frequency
- Once daily
- Tracking Notes
- Monitor biochemistries weekly during initiation or dosage adjustment phases.
- Body Weight
- 11-15 kg
- Dose
- 0.5 to 0.75 mcg
- Frequency
- Once daily
- Tracking Notes
- Ensure patient maintains adequate dietary calcium intake.
- Body Weight
- 16-20 kg
- Dose
- 0.75 to 1 mcg
- Frequency
- Once daily
- Tracking Notes
- Children weighing over 20 kg generally tolerate starting doses of 1 mcg daily.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.05 to 0.1 mcg/kg | Once daily | Must be initiated and monitored strictly by a specialist. High risk of hypercalcemia in neonates. |
| 5-7 kg | 0.25 mcg | Once daily | Dose titrated based on regular serum calcium determinations. |
| 8-10 kg | 0.4 to 0.5 mcg | Once daily | Monitor biochemistries weekly during initiation or dosage adjustment phases. |
| 11-15 kg | 0.5 to 0.75 mcg | Once daily | Ensure patient maintains adequate dietary calcium intake. |
| 16-20 kg | 0.75 to 1 mcg | Once daily | Children weighing over 20 kg generally tolerate starting doses of 1 mcg daily. |
Formulation
Purpose
Used to treat and manage diseases caused by disturbances in calcium metabolism, such as renal osteodystrophy, hypoparathyroidism, pseudohypoparathyroidism, nutritional or metabolic rickets, osteomalacia, and postmenopausal osteoporosis.
Generic Name
AlfacalcidolScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.