One Alpha
One-Alpha contains alfacalcidol, a vitamin D analogue. It is rapidly converted in the liver to 1,25-dihydroxyvitamin D3 (calcitriol), the active form of vitamin D that regulates calcium and phosphate absorption and bone mineralization.
Dosage by Body Weight
Dosages must be individualized and adjusted under strict medical supervision based on regular monitoring of serum calcium levels. The usual adult starting dose is 1 microgram daily.
- Body Weight
- Below 5 kg
- Dose
- 0.05 to 0.1 mcg/kg daily
- Frequency
- Once daily
- Tracking Notes
- Initiation should be closely supervised by a specialist; monitor serum calcium levels weekly.
- Body Weight
- 5-7 kg
- Dose
- 0.25 mcg to 0.5 mcg daily
- Frequency
- Once daily
- Tracking Notes
- Dose is adjusted according to biochemical responses and plasma calcium levels.
- Body Weight
- 8-10 kg
- Dose
- 0.4 mcg to 0.5 mcg daily
- Frequency
- Once daily
- Tracking Notes
- Maintain regular blood tests to check calcium, phosphate, and alkaline phosphatase.
- Body Weight
- 11-15 kg
- Dose
- 0.5 mcg to 0.75 mcg daily
- Frequency
- Once daily
- Tracking Notes
- Adjustment must be tailored to maintain serum calcium within the normal range.
- Body Weight
- 16-20 kg
- Dose
- 0.8 mcg to 1.0 mcg daily
- Frequency
- Once daily
- Tracking Notes
- Do not exceed the maximum prescribed pediatric dose. Ensure adequate calcium intake.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.05 to 0.1 mcg/kg daily | Once daily | Initiation should be closely supervised by a specialist; monitor serum calcium levels weekly. |
| 5-7 kg | 0.25 mcg to 0.5 mcg daily | Once daily | Dose is adjusted according to biochemical responses and plasma calcium levels. |
| 8-10 kg | 0.4 mcg to 0.5 mcg daily | Once daily | Maintain regular blood tests to check calcium, phosphate, and alkaline phosphatase. |
| 11-15 kg | 0.5 mcg to 0.75 mcg daily | Once daily | Adjustment must be tailored to maintain serum calcium within the normal range. |
| 16-20 kg | 0.8 mcg to 1.0 mcg daily | Once daily | Do not exceed the maximum prescribed pediatric dose. Ensure adequate calcium intake. |
Formulation
Purpose
Used to treat conditions where calcium and phosphate metabolism is disturbed due to impaired 1-hydroxylation, such as renal osteodystrophy, hypoparathyroidism, hyperparathyroidism, and nutritional or metabolic rickets/osteomalacia.
Generic Name
AlfacalcidolScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.