Nitroglycerin Injection
Nitroglycerin injection is an intravenous vasodilator that acts predominantly on venous smooth muscle to reduce preload, and at higher doses, reduces arterial resistance (afterload). It is rapidly metabolized and requires continuous blood pressure monitoring.
Dosage by Body Weight
Administer only via continuous intravenous infusion using an infusion pump. Dilution in 5% Dextrose or 0.9% Sodium Chloride is required. Start at 5 mcg/min and titrate based on hemodynamic response. Do not administer by direct IV bolus.
- Body Weight
- Below 5 kg
- Dose
- 0.25 to 1.0 mcg/kg/min
- Frequency
- Continuous IV infusion
- Tracking Notes
- Requires intensive care monitoring. Titrate slowly to avoid severe hypotension.
- Body Weight
- 5-7 kg
- Dose
- 1.25 to 7.0 mcg/min
- Frequency
- Continuous IV infusion
- Tracking Notes
- Calculate exact dose based on patient's weight in kg and clinical response.
- Body Weight
- 8-10 kg
- Dose
- 2.0 to 10.0 mcg/min
- Frequency
- Continuous IV infusion
- Tracking Notes
- Monitor arterial blood pressure and heart rate continuously.
- Body Weight
- 11-15 kg
- Dose
- 2.75 to 15.0 mcg/min
- Frequency
- Continuous IV infusion
- Tracking Notes
- Adjust infusion rate in small increments every 3 to 5 minutes.
- Body Weight
- 16-20 kg
- Dose
- 4.0 to 20.0 mcg/min
- Frequency
- Continuous IV infusion
- Tracking Notes
- Use non-PVC infusion sets as nitroglycerin migrates into standard PVC plastics.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.25 to 1.0 mcg/kg/min | Continuous IV infusion | Requires intensive care monitoring. Titrate slowly to avoid severe hypotension. |
| 5-7 kg | 1.25 to 7.0 mcg/min | Continuous IV infusion | Calculate exact dose based on patient's weight in kg and clinical response. |
| 8-10 kg | 2.0 to 10.0 mcg/min | Continuous IV infusion | Monitor arterial blood pressure and heart rate continuously. |
| 11-15 kg | 2.75 to 15.0 mcg/min | Continuous IV infusion | Adjust infusion rate in small increments every 3 to 5 minutes. |
| 16-20 kg | 4.0 to 20.0 mcg/min | Continuous IV infusion | Use non-PVC infusion sets as nitroglycerin migrates into standard PVC plastics. |
Formulation
Purpose
Used for treatment of congestive heart failure associated with acute myocardial infarction, control of peri-operative hypertension, treatment of angina pectoris unresponsive to standard therapy, and induction of controlled hypotension during surgery.
Generic Name
NitroglycerinBranded Drug Names
Nitroglycerin Injection is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.