Imipramine
Imipramine is a tricyclic antidepressant (TCA) that works by inhibiting the reuptake of neurotransmitters like serotonin and norepinephrine in the central nervous system. It also exhibits significant anticholinergic activity, which contributes to its utility in managing nocturnal enuresis.
Dosage by Body Weight
For depression in adults, the typical starting dose is 75 mg daily in divided doses, titrated up to 150-200 mg daily as tolerated. For nocturnal enuresis in children aged 6 and older, the typical dose is 25 mg taken 1 hour before bedtime; if no response is seen within a week, it may be increased to 50 mg (for children under 12 years) or 75 mg (for children 12 years and older).
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Contraindicated in infants and neonates due to a high risk of severe toxicity.
- Body Weight
- 5-7 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Safety and effectiveness have not been established in pediatric patients under 6 years of age.
- Body Weight
- 8-10 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Safety and effectiveness have not been established in pediatric patients under 6 years of age.
- Body Weight
- 11-15 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Safety and effectiveness have not been established in pediatric patients under 6 years of age.
- Body Weight
- 16-20 kg
- Dose
- Not recommended
- Frequency
- Do not use
- Tracking Notes
- Use only under strict specialist supervision if specifically prescribed for children over 6 years of age who fall into this weight range.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | Do not use | Contraindicated in infants and neonates due to a high risk of severe toxicity. |
| 5-7 kg | Not recommended | Do not use | Safety and effectiveness have not been established in pediatric patients under 6 years of age. |
| 8-10 kg | Not recommended | Do not use | Safety and effectiveness have not been established in pediatric patients under 6 years of age. |
| 11-15 kg | Not recommended | Do not use | Safety and effectiveness have not been established in pediatric patients under 6 years of age. |
| 16-20 kg | Not recommended | Do not use | Use only under strict specialist supervision if specifically prescribed for children over 6 years of age who fall into this weight range. |
Formulation
Purpose
Used primarily for the treatment of major depressive disorder (depression) and as temporary adjunctive therapy in the treatment of nocturnal enuresis (bedwetting) in children aged 6 years and older.
Generic Name
ImipramineBranded Drug Names
Imipramine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.