Enoximone

Enoximone is a selective phosphodiesterase III (PDE3) inhibitor with positive inotropic and vasodilator properties. It increases cardiac contractility and reduces systemic and pulmonary vascular resistance (preload and afterload), thereby improving cardiac output without significantly increasing myocardial oxygen consumption.

Dosage by Body Weight

For intravenous use only in specialized intensive care settings. Loading dose is typically 0.5 to 1.0 mg/kg administered slowly over 5 to 10 minutes. Maintenance therapy can be maintained via continuous infusion at a rate of 5 to 20 micrograms/kg/minute. Total daily dose should not exceed 24 mg/kg.

Body Weight
Below 5 kg
Dose
0.5 - 1.0 mg/kg slow IV bolus
Frequency
As directed by specialist
Tracking Notes
Use extreme caution. Limited pediatric safety data available. Requires continuous ECG and hemodynamic monitoring.
Body Weight
5-7 kg
Dose
2.5 - 7.0 mg slow IV bolus
Frequency
As directed by specialist
Tracking Notes
Administer slowly over 10 minutes. Follow with maintenance infusion of 5-20 mcg/kg/min if required.
Body Weight
8-10 kg
Dose
4.0 - 10.0 mg slow IV bolus
Frequency
As directed by specialist
Tracking Notes
Adjust dose according to hemodynamic response and renal function.
Body Weight
11-15 kg
Dose
5.5 - 15.0 mg slow IV bolus
Frequency
As directed by specialist
Tracking Notes
Do not exceed maximum daily cumulative dose of 24 mg/kg.
Body Weight
16-20 kg
Dose
8.0 - 20.0 mg slow IV bolus
Frequency
As directed by specialist
Tracking Notes
Monitor blood pressure closely during administration due to potential for hypotension.

Weight-based dosage tracking table for Enoximone, including body weight, dose, frequency, and tracking notes.
Body Weight	Dose	Frequency	Tracking Notes
Below 5 kg	0.5 - 1.0 mg/kg slow IV bolus	As directed by specialist	Use extreme caution. Limited pediatric safety data available. Requires continuous ECG and hemodynamic monitoring.
5-7 kg	2.5 - 7.0 mg slow IV bolus	As directed by specialist	Administer slowly over 10 minutes. Follow with maintenance infusion of 5-20 mcg/kg/min if required.
8-10 kg	4.0 - 10.0 mg slow IV bolus	As directed by specialist	Adjust dose according to hemodynamic response and renal function.
11-15 kg	5.5 - 15.0 mg slow IV bolus	As directed by specialist	Do not exceed maximum daily cumulative dose of 24 mg/kg.
16-20 kg	8.0 - 20.0 mg slow IV bolus	As directed by specialist	Monitor blood pressure closely during administration due to potential for hypotension.

Formulation

Injection (Intravenous Solution)

Purpose

Short-term treatment of severe congestive heart failure and acute heart failure following cardiac surgery.

Generic Name

Enoximone

Branded Drug Names

Enoximone is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Milrinone Dobutamine Levosimendan