Doxercalciferol
Doxercalciferol is a synthetic vitamin D2 analog. It undergoes metabolic activation in the liver to form 1,25-dihydroxyvitamin D2, which acts as a vitamin D receptor agonist to suppress parathyroid hormone (PTH) synthesis and secretion.
Dosage by Body Weight
Dosage must be individualized and highly monitored based on serum calcium, phosphorus, and intact parathyroid hormone (iPTH) levels. Oral doses are typically taken 3 times weekly (for dialysis patients) or once daily (for Stage 3/4 CKD patients).
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients. Use is highly restricted and requires specialist supervision.
- Body Weight
- 5-7 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Dosing is not standard; pediatric nephrologist consultation is required with close monitoring of calcium and phosphorus.
- Body Weight
- 8-10 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Strict monitoring of serum iPTH, calcium, and phosphorus is mandatory if prescribed.
- Body Weight
- 11-15 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Requires individualized titration and close medical supervision by a pediatric specialist.
- Body Weight
- 16-20 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Doxercalciferol is not standardly dosed by weight; requires specialist assessment.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy have not been established in pediatric patients. Use is highly restricted and requires specialist supervision. |
| 5-7 kg | Not routine | Use only if prescribed | Dosing is not standard; pediatric nephrologist consultation is required with close monitoring of calcium and phosphorus. |
| 8-10 kg | Not routine | Use only if prescribed | Strict monitoring of serum iPTH, calcium, and phosphorus is mandatory if prescribed. |
| 11-15 kg | Not routine | Use only if prescribed | Requires individualized titration and close medical supervision by a pediatric specialist. |
| 16-20 kg | Not routine | Use only if prescribed | Doxercalciferol is not standardly dosed by weight; requires specialist assessment. |
Formulation
Purpose
Treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD) on dialysis or with Stage 3 or 4 CKD.
Generic Name
DoxercalciferolBranded Drug Names
Doxercalciferol is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.