Bosentan
An endothelin receptor antagonist. It helps lower blood pressure in the lungs and improve exercise capacity.
Dosage by Body Weight
Pediatric dose: 2 mg/kg twice daily. Start at half-dose for 4 weeks. Requires monthly liver function tests.
- Body Weight
- 10-20 kg
- Dose
- 32 mg
- Frequency
- Twice daily
- Tracking Notes
- The 32mg dispersible tablet is specifically designed for children.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 10-20 kg | 32 mg | Twice daily | The 32mg dispersible tablet is specifically designed for children. |
Formulation
Purpose
Treatment of Pulmonary Arterial Hypertension (PAH) in children.
Generic Name
BosentanBranded Drug Names
Bosentan is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONBosentan: Alcohol may worsen palpitations, dizziness, dehydration, or breathing control. Avoid or limit alcohol if symptoms occur.
Pregnancy
SAFE IF PRESCRIBEDBosentan: Use during pregnancy only when prescribed; controlling breathing or pulmonary pressure problems may be essential.
Breast Feeding
SAFE IF PRESCRIBEDBosentan: Use while breastfeeding only as directed; inhaled treatments are often preferred when suitable.
Driving
CAUTIONBosentan: May cause tremor, dizziness, headache, or palpitations. Avoid driving if you feel unwell.
Liver
CAUTIONBosentan: Use with healthcare guidance in significant liver disease or when long-term monitoring is required.
Kidney
CAUTIONBosentan: Use caution in kidney disease, especially if electrolyte changes or blood pressure effects are possible.