Boziat
Boziat contains Bosentan, a dual endothelin receptor antagonist. It blocks the binding of endothelin-1 to ET-A and ET-B receptors, reducing pulmonary vascular resistance. It is highly restricted due to risks of hepatotoxicity and teratogenicity.
Dosage by Body Weight
Standard adult dose is 62.5 mg twice daily for 4 weeks, then increased to 125 mg twice daily. Requires monthly liver function and pregnancy monitoring.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy are not established in this weight range.
- Body Weight
- 5-7 kg
- Dose
- Not routinely recommended
- Frequency
- Consult pediatric specialist
- Tracking Notes
- Limited data available; dosing must be highly individualized.
- Body Weight
- 8-10 kg
- Dose
- 16 mg
- Frequency
- Once daily, can be increased to twice daily
- Tracking Notes
- Typically requires dispersible pediatric formulations. Monitor liver enzymes closely.
- Body Weight
- 11-15 kg
- Dose
- 32 mg
- Frequency
- Twice daily
- Tracking Notes
- Initiate at 16 mg twice daily for 4 weeks before increasing to the target dose of 32 mg twice daily.
- Body Weight
- 16-20 kg
- Dose
- 32 mg
- Frequency
- Twice daily
- Tracking Notes
- Standard pediatric target dose. Closely monitor liver function monthly.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy are not established in this weight range. |
| 5-7 kg | Not routinely recommended | Consult pediatric specialist | Limited data available; dosing must be highly individualized. |
| 8-10 kg | 16 mg | Once daily, can be increased to twice daily | Typically requires dispersible pediatric formulations. Monitor liver enzymes closely. |
| 11-15 kg | 32 mg | Twice daily | Initiate at 16 mg twice daily for 4 weeks before increasing to the target dose of 32 mg twice daily. |
| 16-20 kg | 32 mg | Twice daily | Standard pediatric target dose. Closely monitor liver function monthly. |
Formulation
Tablet
Purpose
Treatment of Pulmonary Arterial Hypertension (PAH) to improve exercise capacity and decrease clinical worsening, and reduction of ongoing digital ulcer disease in systemic sclerosis.
Generic Name
BosentanScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.