Zeffix
Zeffix is an antiviral medication containing lamivudine, a nucleoside reverse transcriptase inhibitor (NRTI). It works by selectively inhibiting hepatitis B virus (HBV) replication in liver cells, reducing viral load and decreasing liver inflammation.
Dosage by Body Weight
The standard adult dose is 100 mg once daily, taken with or without food. For pediatric patients aged 2 to 11 years, the dose is calculated based on body weight (typically 3 mg/kg once daily, up to a maximum of 100 mg per day). Close medical supervision and regular liver function monitoring are required.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in infants under 2 years of age have not been established.
- Body Weight
- 5-7 kg
- Dose
- 15 mg to 21 mg (3.0 mL to 4.2 mL of 5 mg/mL oral solution)
- Frequency
- Once daily
- Tracking Notes
- Pediatric dosing is calculated at 3 mg/kg body weight once daily. Use oral solution for accurate measurement.
- Body Weight
- 8-10 kg
- Dose
- 24 mg to 30 mg (4.8 mL to 6.0 mL of 5 mg/mL oral solution)
- Frequency
- Once daily
- Tracking Notes
- Administer using the graduated oral dosing syringe provided with the formulation.
- Body Weight
- 11-15 kg
- Dose
- 33 mg to 45 mg (6.6 mL to 9.0 mL of 5 mg/mL oral solution)
- Frequency
- Once daily
- Tracking Notes
- Regular clinical and biochemical monitoring is essential during treatment.
- Body Weight
- 16-20 kg
- Dose
- 48 mg to 60 mg (9.6 mL to 12.0 mL of 5 mg/mL oral solution)
- Frequency
- Once daily
- Tracking Notes
- Ensure total daily pediatric dose does not exceed the maximum adult dose of 100 mg.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in infants under 2 years of age have not been established. |
| 5-7 kg | 15 mg to 21 mg (3.0 mL to 4.2 mL of 5 mg/mL oral solution) | Once daily | Pediatric dosing is calculated at 3 mg/kg body weight once daily. Use oral solution for accurate measurement. |
| 8-10 kg | 24 mg to 30 mg (4.8 mL to 6.0 mL of 5 mg/mL oral solution) | Once daily | Administer using the graduated oral dosing syringe provided with the formulation. |
| 11-15 kg | 33 mg to 45 mg (6.6 mL to 9.0 mL of 5 mg/mL oral solution) | Once daily | Regular clinical and biochemical monitoring is essential during treatment. |
| 16-20 kg | 48 mg to 60 mg (9.6 mL to 12.0 mL of 5 mg/mL oral solution) | Once daily | Ensure total daily pediatric dose does not exceed the maximum adult dose of 100 mg. |
Formulation
Purpose
Treatment of chronic hepatitis B virus (HBV) infection in patients with evidence of hepatitis B viral replication and active liver inflammation.
Generic Name
LamivudineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.