Thermazene
Thermazene is a topical prescription antimicrobial cream containing silver sulfadiazine. It is used as an adjunct treatment to prevent and treat bacterial infections in severe burn wounds. It works by damaging the cell membrane and cell wall of a broad spectrum of Gram-negative and Gram-positive bacteria.
Dosage by Body Weight
Cleanse the burn wound and debride any loose tissue. Apply Thermazene cream using a sterile gloved hand to a thickness of approximately 1/16 inch (1.6 mm) to the affected area once or twice daily. The burn wounds should be covered with cream at all times. Reapply immediately if the cream is rubbed or washed off.
- Body Weight
- Below 5 kg
- Dose
- Contraindicated in infants < 2 months
- Frequency
- Do not use
- Tracking Notes
- Contraindicated in premature infants and newborns under 2 months of age due to the risk of kernicterus.
- Body Weight
- 5-7 kg
- Dose
- Apply to 1/16 inch thickness
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Dosage is determined by the size and severity of the burn wound area, not by body weight.
- Body Weight
- 8-10 kg
- Dose
- Apply to 1/16 inch thickness
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Ensure burn wounds are continuously covered with the cream. Reapply if rubbed off.
- Body Weight
- 11-15 kg
- Dose
- Apply to 1/16 inch thickness
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Dosing is topical and localized. Use caution if treating extensive burn areas to monitor for systemic absorption.
- Body Weight
- 16-20 kg
- Dose
- Apply to 1/16 inch thickness
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Monitor renal function if applied to large body surface areas for prolonged periods.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Contraindicated in infants < 2 months | Do not use | Contraindicated in premature infants and newborns under 2 months of age due to the risk of kernicterus. |
| 5-7 kg | Apply to 1/16 inch thickness | 1 to 2 times daily | Dosage is determined by the size and severity of the burn wound area, not by body weight. |
| 8-10 kg | Apply to 1/16 inch thickness | 1 to 2 times daily | Ensure burn wounds are continuously covered with the cream. Reapply if rubbed off. |
| 11-15 kg | Apply to 1/16 inch thickness | 1 to 2 times daily | Dosing is topical and localized. Use caution if treating extensive burn areas to monitor for systemic absorption. |
| 16-20 kg | Apply to 1/16 inch thickness | 1 to 2 times daily | Monitor renal function if applied to large body surface areas for prolonged periods. |
Formulation
Purpose
Prevention and treatment of wound infection (sepsis) in patients with second- and third-degree burns
Generic Name
Silver sulfadiazineScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.