Tacrograf
Tacrograf is an immunosuppressant medication containing Tacrolimus. It belongs to the class of calcineurin inhibitors and works by reducing the activity of the body's immune system to prevent it from attacking and rejecting a newly transplanted organ.
Dosage by Body Weight
Dosage must be strictly individualized and managed by a transplant specialist. It is typically taken twice daily (every 12 hours) on an empty stomach (1 hour before or 2 hours after meals) to ensure consistent absorption. Routine blood concentration monitoring is mandatory to adjust doses.
- Body Weight
- Below 5 kg
- Dose
- 0.15 to 0.3 mg/kg/day starting dose
- Frequency
- Divided into two doses (every 12 hours)
- Tracking Notes
- Highly critical. Dosage must be titrated strictly based on blood trough levels and transplant protocol.
- Body Weight
- 5-7 kg
- Dose
- 0.5 mg to 2.1 mg per day (total)
- Frequency
- Divided into two doses (every 12 hours)
- Tracking Notes
- Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring.
- Body Weight
- 8-10 kg
- Dose
- 0.8 mg to 3.0 mg per day (total)
- Frequency
- Divided into two doses (every 12 hours)
- Tracking Notes
- Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring.
- Body Weight
- 11-15 kg
- Dose
- 1.1 mg to 4.5 mg per day (total)
- Frequency
- Divided into two doses (every 12 hours)
- Tracking Notes
- Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring.
- Body Weight
- 16-20 kg
- Dose
- 1.6 mg to 6.0 mg per day (total)
- Frequency
- Divided into two doses (every 12 hours)
- Tracking Notes
- Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.15 to 0.3 mg/kg/day starting dose | Divided into two doses (every 12 hours) | Highly critical. Dosage must be titrated strictly based on blood trough levels and transplant protocol. |
| 5-7 kg | 0.5 mg to 2.1 mg per day (total) | Divided into two doses (every 12 hours) | Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring. |
| 8-10 kg | 0.8 mg to 3.0 mg per day (total) | Divided into two doses (every 12 hours) | Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring. |
| 11-15 kg | 1.1 mg to 4.5 mg per day (total) | Divided into two doses (every 12 hours) | Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring. |
| 16-20 kg | 1.6 mg to 6.0 mg per day (total) | Divided into two doses (every 12 hours) | Calculated based on 0.1-0.3 mg/kg/day. Requires regular blood trough level monitoring. |
Formulation
Purpose
Prevention of organ transplant rejection in patients receiving allogeneic liver, kidney, or heart transplants.
Generic Name
TacrolimusScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.