Pangraf
Pangraf contains Tacrolimus, a potent immunosuppressant medication. It works by inhibiting T-lymphocyte activation, thereby suppressing the body's immune system to prevent it from recognizing and rejecting a transplanted organ.
Dosage by Body Weight
Dosage of Pangraf is highly critical and must be strictly individualized for each patient. It is initiated by a transplant specialist based on the type of organ transplanted, body weight, and adjusted dynamically using regular blood trough level monitoring.
- Body Weight
- Below 5 kg
- Dose
- Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day)
- Frequency
- Twice daily (every 12 hours)
- Tracking Notes
- Requires highly specialized pediatric transplant management and intensive blood level monitoring.
- Body Weight
- 5-7 kg
- Dose
- Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day)
- Frequency
- Twice daily (every 12 hours)
- Tracking Notes
- Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL).
- Body Weight
- 8-10 kg
- Dose
- Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day)
- Frequency
- Twice daily (every 12 hours)
- Tracking Notes
- Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL).
- Body Weight
- 11-15 kg
- Dose
- Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day)
- Frequency
- Twice daily (every 12 hours)
- Tracking Notes
- Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL).
- Body Weight
- 16-20 kg
- Dose
- Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day)
- Frequency
- Twice daily (every 12 hours)
- Tracking Notes
- Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL).
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day) | Twice daily (every 12 hours) | Requires highly specialized pediatric transplant management and intensive blood level monitoring. |
| 5-7 kg | Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day) | Twice daily (every 12 hours) | Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL). |
| 8-10 kg | Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day) | Twice daily (every 12 hours) | Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL). |
| 11-15 kg | Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day) | Twice daily (every 12 hours) | Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL). |
| 16-20 kg | Strictly calculated by specialist (e.g., 0.1 - 0.2 mg/kg/day) | Twice daily (every 12 hours) | Dose must be adjusted to maintain therapeutic target blood levels (typically 5-20 ng/mL). |
Formulation
Capsule
Purpose
Prevention of organ rejection in kidney, liver, or heart transplant recipients.
Generic Name
TacrolimusScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.