Sotylize
Sotylize is an oral solution formulation of sotalol hydrochloride, a class II and III antiarrhythmic agent. It blocks both beta-adrenergic receptors and cardiac potassium channels to help maintain normal heart rhythms.
Dosage by Body Weight
Therapy must be initiated and up-titrated in a facility that can provide continuous ECG monitoring and cardiac resuscitation. Dosages are highly individualized and must be adjusted based on renal function (creatinine clearance) and QTc intervals. For pediatric patients, dosing is calculated using Body Surface Area (BSA) and adjusted using age-related correction factors for infants under 2 years.
- Body Weight
- Below 5 kg
- Dose
- Must be calculated individually using BSA and age-related correction factors
- Frequency
- Typically every 8 hours (3 times daily)
- Tracking Notes
- Infants under 2 years of age require a specific dosage reduction factor due to immature renal function. Dosing must be initiated in a hospital setting under expert supervision.
- Body Weight
- 5-7 kg
- Dose
- Must be calculated individually using BSA and age-related correction factors
- Frequency
- Typically every 8 hours (3 times daily)
- Tracking Notes
- Highly dependent on the child's exact age and renal development. Requires initiation in a specialized hospital setting with continuous ECG monitoring.
- Body Weight
- 8-10 kg
- Dose
- Must be calculated individually using BSA
- Frequency
- Typically every 8 hours (3 times daily)
- Tracking Notes
- Dosing starts at approximately 30 mg/m² per dose (90 mg/m²/day total) and is titrated based on clinical response and QTc interval.
- Body Weight
- 11-15 kg
- Dose
- Must be calculated individually using BSA
- Frequency
- Typically every 8 hours (3 times daily) or every 12 hours depending on clinical protocol
- Tracking Notes
- Titration should progress slowly, with at least 36 hours between dose increments to allow monitoring of steady-state QTc intervals.
- Body Weight
- 16-20 kg
- Dose
- Must be calculated individually using BSA
- Frequency
- Typically every 8 hours (3 times daily) or every 12 hours depending on clinical protocol
- Tracking Notes
- Pediatric dosing guidelines recommend scaling from adult doses using body surface area calculations. Always verify calculations with a pediatric cardiologist.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Must be calculated individually using BSA and age-related correction factors | Typically every 8 hours (3 times daily) | Infants under 2 years of age require a specific dosage reduction factor due to immature renal function. Dosing must be initiated in a hospital setting under expert supervision. |
| 5-7 kg | Must be calculated individually using BSA and age-related correction factors | Typically every 8 hours (3 times daily) | Highly dependent on the child's exact age and renal development. Requires initiation in a specialized hospital setting with continuous ECG monitoring. |
| 8-10 kg | Must be calculated individually using BSA | Typically every 8 hours (3 times daily) | Dosing starts at approximately 30 mg/m² per dose (90 mg/m²/day total) and is titrated based on clinical response and QTc interval. |
| 11-15 kg | Must be calculated individually using BSA | Typically every 8 hours (3 times daily) or every 12 hours depending on clinical protocol | Titration should progress slowly, with at least 36 hours between dose increments to allow monitoring of steady-state QTc intervals. |
| 16-20 kg | Must be calculated individually using BSA | Typically every 8 hours (3 times daily) or every 12 hours depending on clinical protocol | Pediatric dosing guidelines recommend scaling from adult doses using body surface area calculations. Always verify calculations with a pediatric cardiologist. |
Formulation
Purpose
Treatment of documented life-threatening ventricular arrhythmias, and maintenance of normal sinus rhythm in patients with highly symptomatic atrial fibrillation or atrial flutter.
Generic Name
Sotalol HydrochlorideScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.