Quinine Injection
Quinine Injection is an alkaloid antimalarial agent used primarily in intensive care settings for the treatment of life-threatening malaria infections. It works by interfering with the parasite's ability to digest hemoglobin. It must be administered under strict medical supervision due to potential cardiovascular toxicity and risk of severe hypoglycemia.
Dosage by Body Weight
Administered via slow intravenous infusion over 4 hours. A loading dose of 20 mg/kg may be given, followed by maintenance doses of 10 mg/kg every 8 hours. Switch to oral therapy as soon as the patient can tolerate it.
- Body Weight
- Below 5 kg
- Dose
- 10 mg/kg (maintenance dose)
- Frequency
- Every 8 hours
- Tracking Notes
- Dilute in 5-10 ml/kg of 5% dextrose. Infuse over 4 hours. Monitor blood glucose closely.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 70 mg (maintenance dose)
- Frequency
- Every 8 hours
- Tracking Notes
- Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose.
- Body Weight
- 8-10 kg
- Dose
- 80 mg to 100 mg (maintenance dose)
- Frequency
- Every 8 hours
- Tracking Notes
- Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose.
- Body Weight
- 11-15 kg
- Dose
- 110 mg to 150 mg (maintenance dose)
- Frequency
- Every 8 hours
- Tracking Notes
- Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose.
- Body Weight
- 16-20 kg
- Dose
- 160 mg to 200 mg (maintenance dose)
- Frequency
- Every 8 hours
- Tracking Notes
- Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 10 mg/kg (maintenance dose) | Every 8 hours | Dilute in 5-10 ml/kg of 5% dextrose. Infuse over 4 hours. Monitor blood glucose closely. |
| 5-7 kg | 50 mg to 70 mg (maintenance dose) | Every 8 hours | Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose. |
| 8-10 kg | 80 mg to 100 mg (maintenance dose) | Every 8 hours | Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose. |
| 11-15 kg | 110 mg to 150 mg (maintenance dose) | Every 8 hours | Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose. |
| 16-20 kg | 160 mg to 200 mg (maintenance dose) | Every 8 hours | Dilute in 5% dextrose or 0.9% saline. Infuse over 4 hours. Monitor ECG and blood glucose. |
Formulation
Purpose
Treatment of severe or complicated malaria caused by Plasmodium falciparum when oral therapy is not possible or tolerated.
Generic Name
Quinine DihydrochlorideBranded Drug Names
Quinine Injection is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.