Paluther
Paluther is an antimalarial formulation containing Artemether, a fast-acting artemisinin derivative. It is highly effective in clearing malaria parasites from the blood, and is commonly used as an intramuscular injection for severe malaria before transitioning to oral therapy.
Dosage by Body Weight
Must be administered under strict medical supervision. Usually given as a deep intramuscular injection. The standard regimen involves a loading dose of 3.2 mg/kg on the first day, followed by a maintenance dose of 1.6 mg/kg daily for 4 subsequent days.
- Body Weight
- Below 5 kg
- Dose
- Requires specialist pediatric evaluation
- Frequency
- As directed by physician
- Tracking Notes
- Safety and efficacy data are limited for infants under 5 kg.
- Body Weight
- 5-7 kg
- Dose
- 16 mg to 22 mg loading dose, then 8 mg to 11 mg maintenance dose
- Frequency
- Once daily after loading dose
- Tracking Notes
- Administer via deep intramuscular injection. Rotate injection sites daily.
- Body Weight
- 8-10 kg
- Dose
- 25 mg to 32 mg loading dose, then 12 mg to 16 mg maintenance dose
- Frequency
- Once daily after loading dose
- Tracking Notes
- Switch to oral antimalarial therapy as soon as the patient is able to tolerate oral medication.
- Body Weight
- 11-15 kg
- Dose
- 35 mg to 48 mg loading dose, then 18 mg to 24 mg maintenance dose
- Frequency
- Once daily after loading dose
- Tracking Notes
- Ensure patient is monitored closely for symptoms of recrudescence.
- Body Weight
- 16-20 kg
- Dose
- 50 mg to 64 mg loading dose, then 25 mg to 32 mg maintenance dose
- Frequency
- Once daily after loading dose
- Tracking Notes
- Dose calculations are strictly based on actual body weight to prevent toxicity.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Requires specialist pediatric evaluation | As directed by physician | Safety and efficacy data are limited for infants under 5 kg. |
| 5-7 kg | 16 mg to 22 mg loading dose, then 8 mg to 11 mg maintenance dose | Once daily after loading dose | Administer via deep intramuscular injection. Rotate injection sites daily. |
| 8-10 kg | 25 mg to 32 mg loading dose, then 12 mg to 16 mg maintenance dose | Once daily after loading dose | Switch to oral antimalarial therapy as soon as the patient is able to tolerate oral medication. |
| 11-15 kg | 35 mg to 48 mg loading dose, then 18 mg to 24 mg maintenance dose | Once daily after loading dose | Ensure patient is monitored closely for symptoms of recrudescence. |
| 16-20 kg | 50 mg to 64 mg loading dose, then 25 mg to 32 mg maintenance dose | Once daily after loading dose | Dose calculations are strictly based on actual body weight to prevent toxicity. |
Formulation
Purpose
Treatment of severe and uncomplicated malaria, especially cases caused by multi-drug resistant strains of Plasmodium falciparum.
Generic Name
ArtemetherScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.