Frisium
Frisium contains Clobazam, which belongs to the benzodiazepine class of medicines. It works by enhancing the activity of gamma-aminobutyric acid (GABA), a chemical messenger in the brain that calms excessive nerve activity, thereby reducing seizures and relieving anxiety.
Dosage by Body Weight
Dosage must be strictly individualized and determined by a healthcare provider. It is typically started at a low dose and gradually increased depending on the patient's response and tolerability. Do not discontinue abruptly.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy have not been established for infants in this weight range.
- Body Weight
- 5-7 kg
- Dose
- Not routinely recommended
- Frequency
- Use only under specialist supervision
- Tracking Notes
- Extremely limited data; pediatric neurologist guidance required.
- Body Weight
- 8-10 kg
- Dose
- 0.1 mg to 0.2 mg/kg per day (approx. 1 mg to 2 mg)
- Frequency
- Once daily at bedtime or divided into two doses
- Tracking Notes
- Start with the lowest effective dose and monitor closely for sedation.
- Body Weight
- 11-15 kg
- Dose
- 2.5 mg to 5 mg daily
- Frequency
- Once daily at bedtime or divided into two doses
- Tracking Notes
- Dose may be adjusted slowly by a physician depending on clinical response.
- Body Weight
- 16-20 kg
- Dose
- 5 mg daily (up to a maximum of 10 mg based on tolerability)
- Frequency
- Once daily at bedtime or divided into two doses
- Tracking Notes
- Watch for signs of central nervous system depression or breathing difficulties.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | Use only if prescribed | Safety and efficacy have not been established for infants in this weight range. |
| 5-7 kg | Not routinely recommended | Use only under specialist supervision | Extremely limited data; pediatric neurologist guidance required. |
| 8-10 kg | 0.1 mg to 0.2 mg/kg per day (approx. 1 mg to 2 mg) | Once daily at bedtime or divided into two doses | Start with the lowest effective dose and monitor closely for sedation. |
| 11-15 kg | 2.5 mg to 5 mg daily | Once daily at bedtime or divided into two doses | Dose may be adjusted slowly by a physician depending on clinical response. |
| 16-20 kg | 5 mg daily (up to a maximum of 10 mg based on tolerability) | Once daily at bedtime or divided into two doses | Watch for signs of central nervous system depression or breathing difficulties. |
Formulation
Purpose
Used as an adjunctive treatment for epilepsy (seizures, particularly Lennox-Gastaut syndrome) and for the short-term relief of acute, severe anxiety.
Generic Name
ClobazamScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.