Onfi
Onfi (clobazam) is an antiepileptic drug belonging to the benzodiazepine class. It is primarily used as an add-on therapy for managing seizures associated with Lennox-Gastaut syndrome.
Dosage by Body Weight
Dosage is highly individualized and determined by body weight (under or over 30 kg). It is initiated at a low dose and slowly titrated upward. It should not be discontinued abruptly to avoid withdrawal symptoms.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in patients younger than 2 years of age.
- Body Weight
- 5-7 kg
- Dose
- Not routine
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients under 2 years of age.
- Body Weight
- 8-10 kg
- Dose
- Starting: 5 mg daily; Max: 20 mg daily
- Frequency
- Once daily or divided twice daily
- Tracking Notes
- Applies to patients <= 30 kg. Dose titration should occur weekly based on response and tolerability.
- Body Weight
- 11-15 kg
- Dose
- Starting: 5 mg daily; Max: 20 mg daily
- Frequency
- Once daily or divided twice daily
- Tracking Notes
- Applies to patients <= 30 kg. Doses above 5 mg/day should be administered in divided doses.
- Body Weight
- 16-20 kg
- Dose
- Starting: 5 mg daily; Max: 20 mg daily
- Frequency
- Once daily or divided twice daily
- Tracking Notes
- Applies to patients <= 30 kg. Doses above 5 mg/day should be administered in divided doses.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in patients younger than 2 years of age. |
| 5-7 kg | Not routine | N/A | Safety and efficacy have not been established in pediatric patients under 2 years of age. |
| 8-10 kg | Starting: 5 mg daily; Max: 20 mg daily | Once daily or divided twice daily | Applies to patients <= 30 kg. Dose titration should occur weekly based on response and tolerability. |
| 11-15 kg | Starting: 5 mg daily; Max: 20 mg daily | Once daily or divided twice daily | Applies to patients <= 30 kg. Doses above 5 mg/day should be administered in divided doses. |
| 16-20 kg | Starting: 5 mg daily; Max: 20 mg daily | Once daily or divided twice daily | Applies to patients <= 30 kg. Doses above 5 mg/day should be administered in divided doses. |
Formulation
TabletOral Suspension
Purpose
Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age and older.
Generic Name
ClobazamScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.