Destolit
Destolit contains Ursodeoxycholic acid (ursodiol), a naturally occurring bile acid that helps reduce the amount of cholesterol released by the liver and slowly dissolves cholesterol-based gallstones. It is also used to manage primary biliary cholangitis and prevent gallstone formation in patients undergoing rapid weight loss.
Dosage by Body Weight
The usual dosage is determined by body weight and the specific condition being treated, typically ranging from 8 to 15 mg per kg of body weight daily. It is usually taken either as a single dose at bedtime or divided into multiple doses throughout the day, preferably with food.
- Body Weight
- Below 5 kg
- Dose
- 25 mg to 50 mg daily
- Frequency
- Divided into 2 doses daily
- Tracking Notes
- Use only under strict specialist supervision. Requires liquid suspension formulation for accurate dosing.
- Body Weight
- 5-7 kg
- Dose
- 50 mg to 100 mg daily
- Frequency
- Divided into 2 doses daily
- Tracking Notes
- Liquid formulation (suspension) is preferred for precise measurement.
- Body Weight
- 8-10 kg
- Dose
- 100 mg to 150 mg daily
- Frequency
- Divided into 2 doses daily
- Tracking Notes
- May use suspension or crushed tablet dispersed in water if authorized by a doctor.
- Body Weight
- 11-15 kg
- Dose
- 150 mg to 225 mg daily
- Frequency
- Divided into 2 doses daily
- Tracking Notes
- Ensure exact dosing is managed, utilizing appropriate tablet fractions or suspension.
- Body Weight
- 16-20 kg
- Dose
- 200 mg to 300 mg daily
- Frequency
- Divided into 2 doses daily
- Tracking Notes
- Can transition to standard tablet forms if the patient is able to swallow tablets safely.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 25 mg to 50 mg daily | Divided into 2 doses daily | Use only under strict specialist supervision. Requires liquid suspension formulation for accurate dosing. |
| 5-7 kg | 50 mg to 100 mg daily | Divided into 2 doses daily | Liquid formulation (suspension) is preferred for precise measurement. |
| 8-10 kg | 100 mg to 150 mg daily | Divided into 2 doses daily | May use suspension or crushed tablet dispersed in water if authorized by a doctor. |
| 11-15 kg | 150 mg to 225 mg daily | Divided into 2 doses daily | Ensure exact dosing is managed, utilizing appropriate tablet fractions or suspension. |
| 16-20 kg | 200 mg to 300 mg daily | Divided into 2 doses daily | Can transition to standard tablet forms if the patient is able to swallow tablets safely. |
Formulation
Purpose
Used to dissolve cholesterol gallstones and to treat primary biliary cholangitis (a chronic liver disease).
Generic Name
Ursodeoxycholic acidScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.