Actigall
Actigall (ursodiol) is a naturally occurring bile acid that helps reduce the amount of cholesterol produced by the liver and absorbed by the intestines. This action helps dissolve cholesterol-based gallstones and prevents them from forming in high-risk patients.
Dosage by Body Weight
The usual adult dosage for gallstone dissolution is 8 to 10 mg/kg/day, taken in 2 or 3 divided doses. For the prevention of gallstones during rapid weight loss, the standard dosage is 300 mg taken twice daily. Actigall should be taken with food.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in pediatric patients have not been established. Requires compounded liquid formulation if prescribed.
- Body Weight
- 5-7 kg
- Dose
- 75 mg to 140 mg daily in divided doses
- Frequency
- 2 times daily
- Tracking Notes
- Requires a pharmacist to compound the capsules into a liquid suspension for accurate weight-based dosing.
- Body Weight
- 8-10 kg
- Dose
- 120 mg to 200 mg daily in divided doses
- Frequency
- 2 times daily
- Tracking Notes
- Requires compounded liquid suspension for accurate dosing.
- Body Weight
- 11-15 kg
- Dose
- 165 mg to 300 mg daily in divided doses
- Frequency
- 2 times daily
- Tracking Notes
- May use compounded liquid suspension. 300 mg is the minimum commercial capsule strength.
- Body Weight
- 16-20 kg
- Dose
- 240 mg to 400 mg daily in divided doses
- Frequency
- 2 times daily
- Tracking Notes
- A single 300 mg capsule daily may be considered under direct medical supervision.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in pediatric patients have not been established. Requires compounded liquid formulation if prescribed. |
| 5-7 kg | 75 mg to 140 mg daily in divided doses | 2 times daily | Requires a pharmacist to compound the capsules into a liquid suspension for accurate weight-based dosing. |
| 8-10 kg | 120 mg to 200 mg daily in divided doses | 2 times daily | Requires compounded liquid suspension for accurate dosing. |
| 11-15 kg | 165 mg to 300 mg daily in divided doses | 2 times daily | May use compounded liquid suspension. 300 mg is the minimum commercial capsule strength. |
| 16-20 kg | 240 mg to 400 mg daily in divided doses | 2 times daily | A single 300 mg capsule daily may be considered under direct medical supervision. |
Formulation
Purpose
Used for dissolving radiolucent, non-calcified gallstones and preventing gallstone formation in obese patients undergoing rapid weight loss.
Generic Name
UrsodiolScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.