Glycopyrrolate
Glycopyrrolate is a synthetic quaternary ammonium anticholinergic agent. It competitively blocks acetylcholine at muscarinic receptors, thereby reducing salivary, bronchial, and pharyngeal secretions, decreasing gastric acid volume and acidity, and preventing cardiac vagal inhibitory reflexes during anesthesia.
Dosage by Body Weight
Dosage must be individualized. For pediatric drooling, oral solution dosing is weight-based, starting at 0.02 mg/kg three times daily and titrated upward by 0.02 mg/kg increments every 5 to 7 days based on response and tolerance, up to a maximum of 0.1 mg/kg three times daily (not to exceed 1.5 mg to 3.0 mg per dose). Administer at least 1 hour before or 2 hours after meals.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy are not established in children under 3 years of age or extremely low body weight.
- Body Weight
- 5-7 kg
- Dose
- 0.1 mg to 0.6 mg
- Frequency
- 3 times daily
- Tracking Notes
- Start at 0.1 mg. Titrate up slowly to a maximum of 0.6 mg per dose as tolerated.
- Body Weight
- 8-10 kg
- Dose
- 0.15 mg to 1.0 mg
- Frequency
- 3 times daily
- Tracking Notes
- Start at 0.15 mg to 0.2 mg. Titrate up to a maximum of 1.0 mg per dose.
- Body Weight
- 11-15 kg
- Dose
- 0.2 mg to 1.5 mg
- Frequency
- 3 times daily
- Tracking Notes
- Start at 0.2 mg to 0.3 mg. Titrate up to a maximum of 1.5 mg per dose.
- Body Weight
- 16-20 kg
- Dose
- 0.3 mg to 1.8 mg
- Frequency
- 3 times daily
- Tracking Notes
- Start at 0.3 mg to 0.4 mg. Titrate up to a maximum of 1.8 mg per dose.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy are not established in children under 3 years of age or extremely low body weight. |
| 5-7 kg | 0.1 mg to 0.6 mg | 3 times daily | Start at 0.1 mg. Titrate up slowly to a maximum of 0.6 mg per dose as tolerated. |
| 8-10 kg | 0.15 mg to 1.0 mg | 3 times daily | Start at 0.15 mg to 0.2 mg. Titrate up to a maximum of 1.0 mg per dose. |
| 11-15 kg | 0.2 mg to 1.5 mg | 3 times daily | Start at 0.2 mg to 0.3 mg. Titrate up to a maximum of 1.5 mg per dose. |
| 16-20 kg | 0.3 mg to 1.8 mg | 3 times daily | Start at 0.3 mg to 0.4 mg. Titrate up to a maximum of 1.8 mg per dose. |
Formulation
Purpose
Used to treat peptic ulcers in adults, reduce chronic severe drooling (sialorrhea) in pediatric patients with neurological conditions, and decrease respiratory and salivary secretions during anesthesia.
Generic Name
GlycopyrrolateBranded Drug Names
Glycopyrrolate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.