Amitriptyline

Increases levels of norepinephrine and serotonin. In bedwetting, it acts by reducing sleep depth and increasing bladder capacity.

Dosage by Body Weight

For bedwetting: dose is usually 10-25 mg at bedtime. Requires cardiac monitoring if used at high doses.

Body Weight
Children 7-12 years
Dose
10 mg to 25 mg
Frequency
Once nightly
Tracking Notes
Monitor for dry mouth or blurred vision.

Weight-based dosage tracking table for Amitriptyline, including body weight, dose, frequency, and tracking notes.
Body Weight	Dose	Frequency	Tracking Notes
Children 7-12 years	10 mg to 25 mg	Once nightly	Monitor for dry mouth or blurred vision.

Formulation

Tablet

Purpose

Tricyclic antidepressant used for nocturnal enuresis (bedwetting) and neuropathic pain in children.

Generic Name

Amitriptyline Hydrochloride

Branded Drug Names

Amitriptyline is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Desmopressin Imipramine

Safety Advice

Alcohol

UNSAFE

Amitriptyline: Alcohol can worsen drowsiness, mood changes, impaired judgment, or heart rhythm effects. Avoid alcohol unless your prescriber confirms it is safe.

Pregnancy

CAUTION

Amitriptyline: Use in pregnancy only when prescribed after weighing mental health benefits and medicine-specific risks.

Breast Feeding

CAUTION

Amitriptyline: May pass into breast milk. Use while breastfeeding only with specialist guidance and infant monitoring.

Driving

CAUTION

Amitriptyline: May cause sleepiness, dizziness, slowed reaction time, or concentration changes. Avoid driving if affected.

Liver

CAUTION

Amitriptyline: Use caution in liver disease because several psychiatric or sedating medicines are processed by the liver.

Kidney

CAUTION

Amitriptyline: Kidney disease may require monitoring or dose adjustment for some medicines in this group.