Versacloz
Versacloz is a brand-name atypical antipsychotic oral suspension containing clozapine. It is reserved for treatment-resistant schizophrenia and to reduce suicide risk due to its potential to cause severe neutropenia (low white blood cell count). Because of this risk, it is strictly monitored and only available through the Clozapine REMS program.
Dosage by Body Weight
Dosing must be strictly individualized. The starting dose is usually 12.5 mg once or twice daily, titrated upwards slowly by 25 mg to 50 mg per day to a target therapeutic range of 300 mg to 450 mg per day. Routine monitoring of Absolute Neutrophil Count (ANC) is required.
- Body Weight
- Below 5 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients.
- Body Weight
- 5-7 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients.
- Body Weight
- 8-10 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients.
- Body Weight
- 11-15 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients.
- Body Weight
- 16-20 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy have not been established in pediatric patients.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not recommended | N/A | Safety and efficacy have not been established in pediatric patients. |
| 5-7 kg | Not recommended | N/A | Safety and efficacy have not been established in pediatric patients. |
| 8-10 kg | Not recommended | N/A | Safety and efficacy have not been established in pediatric patients. |
| 11-15 kg | Not recommended | N/A | Safety and efficacy have not been established in pediatric patients. |
| 16-20 kg | Not recommended | N/A | Safety and efficacy have not been established in pediatric patients. |
Formulation
Purpose
Treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment, and for reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder.
Generic Name
ClozapineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.