Topirol
Topirol contains Topiramate, an anticonvulsant medication. It is prescribed to treat certain types of seizures (partial onset, primary generalized tonic-clonic, and Lennox-Gastaut syndrome) and to prevent migraine attacks in adults and adolescents. It works by reducing abnormal electrical activity in the brain.
Dosage by Body Weight
Dosage must be highly individualized and titrated slowly. Typically started at a low dose (e.g., 25 mg daily) and increased weekly under medical supervision to minimize side effects. Do not stop taking Topirol suddenly, as it may cause increased seizure frequency.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Safety and efficacy in infants under 2 years of age or below 5 kg have not been established.
- Body Weight
- 5-7 kg
- Dose
- Safety not established
- Frequency
- Use only if prescribed
- Tracking Notes
- Rarely used in this weight range. Highly specialized pediatric neurologist supervision required if initiated.
- Body Weight
- 8-10 kg
- Dose
- Starting dose: 10 mg to 15 mg daily; target maintenance dose: 50 mg to 90 mg daily.
- Frequency
- Divided into two daily doses
- Tracking Notes
- Target dose is approximately 5 to 9 mg/kg/day. Titrate slowly over several weeks.
- Body Weight
- 11-15 kg
- Dose
- Starting dose: 15 mg to 25 mg daily; target maintenance dose: 75 mg to 135 mg daily.
- Frequency
- Divided into two daily doses
- Tracking Notes
- Ensure adequate fluid intake to prevent the formation of kidney stones.
- Body Weight
- 16-20 kg
- Dose
- Starting dose: 25 mg daily; target maintenance dose: 100 mg to 180 mg daily.
- Frequency
- Divided into two daily doses
- Tracking Notes
- Monitor for cognitive side effects, decreased sweating, and increased body temperature (hyperthermia).
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Safety and efficacy in infants under 2 years of age or below 5 kg have not been established. |
| 5-7 kg | Safety not established | Use only if prescribed | Rarely used in this weight range. Highly specialized pediatric neurologist supervision required if initiated. |
| 8-10 kg | Starting dose: 10 mg to 15 mg daily; target maintenance dose: 50 mg to 90 mg daily. | Divided into two daily doses | Target dose is approximately 5 to 9 mg/kg/day. Titrate slowly over several weeks. |
| 11-15 kg | Starting dose: 15 mg to 25 mg daily; target maintenance dose: 75 mg to 135 mg daily. | Divided into two daily doses | Ensure adequate fluid intake to prevent the formation of kidney stones. |
| 16-20 kg | Starting dose: 25 mg daily; target maintenance dose: 100 mg to 180 mg daily. | Divided into two daily doses | Monitor for cognitive side effects, decreased sweating, and increased body temperature (hyperthermia). |
Formulation
Purpose
Treatment of epilepsy (seizures) in adults and children, and prevention of migraine headaches.
Generic Name
TopiramateScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.