Tobramycin Sulfate
Tobramycin sulfate is an aminoglycoside antibiotic derived from Streptomyces tenebrarius. It is bactericidal and works by binding to the 30S and 50S ribosomal subunits of susceptible bacteria, inhibiting protein synthesis and disrupting cell membrane integrity. It is primarily used for severe Gram-negative infections and is administered via injection, inhalation, or topically to the eye.
Dosage by Body Weight
Dosage is highly individualized and must be adjusted based on body weight, severity of infection, renal function, and serum drug concentration monitoring. For systemic administration, standard pediatric dosing is typically 6 to 7.5 mg/kg/day divided into equal doses every 8 hours. Inhalation and ophthalmic formulations have localized dosing regimens.
- Body Weight
- Below 5 kg
- Dose
- 2.0 to 2.5 mg/kg
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Mainly for neonates; interval is highly dependent on gestational/postnatal age and renal function. Serum concentration monitoring is critical.
- Body Weight
- 5-7 kg
- Dose
- 10 to 17.5 mg
- Frequency
- Every 8 to 12 hours
- Tracking Notes
- Calculated based on 2.0 to 2.5 mg/kg per dose. Adjusted for renal clearance.
- Body Weight
- 8-10 kg
- Dose
- 16 to 25 mg
- Frequency
- Every 8 hours
- Tracking Notes
- Calculated based on 2.0 to 2.5 mg/kg per dose. Peak and trough serum level monitoring recommended.
- Body Weight
- 11-15 kg
- Dose
- 22 to 37.5 mg
- Frequency
- Every 8 hours
- Tracking Notes
- Calculated based on 2.0 to 2.5 mg/kg per dose. Ensure adequate hydration during therapy.
- Body Weight
- 16-20 kg
- Dose
- 32 to 50 mg
- Frequency
- Every 8 hours
- Tracking Notes
- Calculated based on 2.0 to 2.5 mg/kg per dose. Infuse intravenously over 20 to 60 minutes.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 2.0 to 2.5 mg/kg | Every 12 to 24 hours | Mainly for neonates; interval is highly dependent on gestational/postnatal age and renal function. Serum concentration monitoring is critical. |
| 5-7 kg | 10 to 17.5 mg | Every 8 to 12 hours | Calculated based on 2.0 to 2.5 mg/kg per dose. Adjusted for renal clearance. |
| 8-10 kg | 16 to 25 mg | Every 8 hours | Calculated based on 2.0 to 2.5 mg/kg per dose. Peak and trough serum level monitoring recommended. |
| 11-15 kg | 22 to 37.5 mg | Every 8 hours | Calculated based on 2.0 to 2.5 mg/kg per dose. Ensure adequate hydration during therapy. |
| 16-20 kg | 32 to 50 mg | Every 8 hours | Calculated based on 2.0 to 2.5 mg/kg per dose. Infuse intravenously over 20 to 60 minutes. |
Formulation
Purpose
Used to treat serious bacterial infections, particularly those caused by Gram-negative organisms like Pseudomonas aeruginosa, including lower respiratory tract infections, urinary tract infections, septicemia, intra-abdominal infections, skin and bone infections, and superficial eye infections.
Generic Name
Tobramycin SulfateBranded Drug Names
Tobramycin Sulfate is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.