Theolair
Theolair contains theophylline, a methylxanthine bronchodilator. It works by relaxing the smooth muscles of the bronchial airways and pulmonary blood vessels, thereby easing breathing difficulties and reducing the lungs' response to irritants.
Dosage by Body Weight
Dosage must be highly individualized. It is typically determined by clinical response and serum theophylline concentration measurements. It is crucial to swallow extended-release tablets whole and not crush or chew them.
- Body Weight
- Below 5 kg
- Dose
- Not routinely recommended
- Frequency
- Use only under strict specialist supervision
- Tracking Notes
- Clearance is extremely variable and decreased in neonates and young infants. Serum concentration monitoring is mandatory.
- Body Weight
- 5-7 kg
- Dose
- 10 to 12 mg/kg/day starting dose
- Frequency
- Divided every 8 to 12 hours depending on formulation
- Tracking Notes
- Requires careful titration. Serum monitoring recommended to maintain therapeutic levels.
- Body Weight
- 8-10 kg
- Dose
- 12 to 14 mg/kg/day starting dose
- Frequency
- Divided every 8 to 12 hours depending on formulation
- Tracking Notes
- Adjustment must be guided by peak serum theophylline concentrations.
- Body Weight
- 11-15 kg
- Dose
- 13 to 16 mg/kg/day starting dose
- Frequency
- Divided every 8 to 12 hours depending on formulation
- Tracking Notes
- Do not exceed standard starting maximums without measuring blood concentrations.
- Body Weight
- 16-20 kg
- Dose
- 13 to 16 mg/kg/day starting dose
- Frequency
- Divided every 8 to 12 hours depending on formulation
- Tracking Notes
- Monitor closely for signs of toxicity such as nausea, vomiting, or persistent headache.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routinely recommended | Use only under strict specialist supervision | Clearance is extremely variable and decreased in neonates and young infants. Serum concentration monitoring is mandatory. |
| 5-7 kg | 10 to 12 mg/kg/day starting dose | Divided every 8 to 12 hours depending on formulation | Requires careful titration. Serum monitoring recommended to maintain therapeutic levels. |
| 8-10 kg | 12 to 14 mg/kg/day starting dose | Divided every 8 to 12 hours depending on formulation | Adjustment must be guided by peak serum theophylline concentrations. |
| 11-15 kg | 13 to 16 mg/kg/day starting dose | Divided every 8 to 12 hours depending on formulation | Do not exceed standard starting maximums without measuring blood concentrations. |
| 16-20 kg | 13 to 16 mg/kg/day starting dose | Divided every 8 to 12 hours depending on formulation | Monitor closely for signs of toxicity such as nausea, vomiting, or persistent headache. |
Formulation
TabletExtended-Release TabletOral Liquid
Purpose
Used for the prevention and treatment of symptoms of asthma, chronic bronchitis, emphysema, and other lung diseases by relaxing and opening the air passages.
Generic Name
TheophyllineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.