Pyrimethamine
A folic acid antagonist. Because it interferes with folate metabolism, it is almost always given with Folinic Acid (Leucovorin) to protect the patient.
Dosage by Body Weight
Toxoplasmosis loading dose: 2 mg/kg for 2 days, then 1 mg/kg daily. Requires Leucovorin rescue.
- Body Weight
- 10-20 kg
- Dose
- 10 mg to 20 mg
- Frequency
- Once daily
- Tracking Notes
- Monitor CBC weekly for signs of bone marrow suppression.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 10-20 kg | 10 mg to 20 mg | Once daily | Monitor CBC weekly for signs of bone marrow suppression. |
Formulation
Purpose
Used in combination with sulfonamides to treat Toxoplasmosis and resistant Malaria.
Generic Name
PyrimethamineBranded Drug Names
Pyrimethamine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONPyrimethamine: Alcohol may worsen dehydration, stomach upset, or interfere with nutritional recovery. Avoid or limit alcohol.
Pregnancy
SAFE IF PRESCRIBEDPyrimethamine: Generally safe in pregnancy when used at recommended doses or as prescribed. Avoid excessive supplementation.
Breast Feeding
SAFEPyrimethamine: Generally compatible with breastfeeding when used at recommended doses. Ask a healthcare provider before high-dose use.
Driving
SAFEPyrimethamine: Usually does not affect driving. Avoid driving only if you feel unwell, dizzy, or weak from the underlying condition.
Liver
SAFE IF PRESCRIBEDPyrimethamine: Usually safe at recommended doses, but high-dose or fat-soluble vitamin use should be medically supervised in liver disease.
Kidney
CAUTIONPyrimethamine: Kidney disease may require avoiding or adjusting minerals and electrolytes such as potassium, magnesium, calcium, or phosphate.