Pyrimethamine
A folic acid antagonist. Because it interferes with folate metabolism, it is almost always given with Folinic Acid (Leucovorin) to protect the patient.
Dosage by Body Weight
Toxoplasmosis loading dose: 2 mg/kg for 2 days, then 1 mg/kg daily. Requires Leucovorin rescue.
- Body Weight
- 10-20 kg
- Dose
- 10 mg to 20 mg
- Frequency
- Once daily
- Tracking Notes
- Monitor CBC weekly for signs of bone marrow suppression.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 10-20 kg | 10 mg to 20 mg | Once daily | Monitor CBC weekly for signs of bone marrow suppression. |
Formulation
Tablet
Purpose
Used in combination with sulfonamides to treat Toxoplasmosis and resistant Malaria.
Generic Name
Pyrimethamine
Branded Drug Names
Pyrimethamine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
- Daraprim
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.