Purodigin

Purodigin is a cardiac glycoside medication containing digitoxin, derived from the foxglove plant (Digitalis purpurea). It increases the force of myocardial contraction (positive inotropic effect) and decreases heart rate (negative chronotropic effect). Due to its exceptionally long half-life (typically 5 to 7 days) and narrow therapeutic index, it has largely been replaced in modern medicine by digoxin, which is cleared more rapidly from the body.

Dosage by Body Weight

Dosage must be highly individualized by a physician based on clinical response, body weight, renal and hepatic function, and serum drug levels. Digitoxin therapy usually begins with a loading (digitalizing) dose followed by a daily maintenance dose. Close monitoring for signs of digitalis toxicity (such as nausea, vomiting, visual disturbances, or arrhythmias) is required.

Body Weight
Below 5 kg
Dose
Strictly individualized
Frequency
As prescribed by a specialist
Tracking Notes
Cardiac glycosides have an extremely narrow therapeutic index. Pediatric dosing requires precise calculation by a specialist based on lean body mass and renal function.
Body Weight
5-7 kg
Dose
Strictly individualized
Frequency
As prescribed by a specialist
Tracking Notes
Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
Body Weight
8-10 kg
Dose
Strictly individualized
Frequency
As prescribed by a specialist
Tracking Notes
Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
Body Weight
11-15 kg
Dose
Strictly individualized
Frequency
As prescribed by a specialist
Tracking Notes
Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
Body Weight
16-20 kg
Dose
Strictly individualized
Frequency
As prescribed by a specialist
Tracking Notes
Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.

Weight-based dosage tracking table for Purodigin, including body weight, dose, frequency, and tracking notes.
Body Weight	Dose	Frequency	Tracking Notes
Below 5 kg	Strictly individualized	As prescribed by a specialist	Cardiac glycosides have an extremely narrow therapeutic index. Pediatric dosing requires precise calculation by a specialist based on lean body mass and renal function.
5-7 kg	Strictly individualized	As prescribed by a specialist	Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
8-10 kg	Strictly individualized	As prescribed by a specialist	Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
11-15 kg	Strictly individualized	As prescribed by a specialist	Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.
16-20 kg	Strictly individualized	As prescribed by a specialist	Requires strict therapeutic drug monitoring and regular ECG evaluation to prevent toxicity.

Formulation

Tablet

Purpose

Treatment of congestive heart failure and control of ventricular rate in patients with atrial fibrillation or atrial flutter.

Generic Name

Digitoxin

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Digoxin Lanoxin Crystodigin