Piperacillin + Tazobactam

An extended-spectrum penicillin combined with a beta-lactamase inhibitor. It is highly effective against Pseudomonas aeruginosa and anaerobic bacteria.

Dosage by Body Weight

Pediatric dose (2 months to 12 years): 100 mg/kg of the piperacillin component every 8 hours. For febrile neutropenia: 80 mg/kg every 6 hours.

Body Weight
5-10 kg
Dose
500 mg to 1,000 mg
Frequency
Every 8 hours
Tracking Notes
Administered via IV infusion over 30 minutes.
Body Weight
11-20 kg
Dose
1.1 g to 2 g
Frequency
Every 8 hours
Tracking Notes
Monitor kidney function and electrolyte levels (sodium).

Weight-based dosage tracking table for Piperacillin + Tazobactam, including body weight, dose, frequency, and tracking notes.
Body Weight	Dose	Frequency	Tracking Notes
5-10 kg	500 mg to 1,000 mg	Every 8 hours	Administered via IV infusion over 30 minutes.
11-20 kg	1.1 g to 2 g	Every 8 hours	Monitor kidney function and electrolyte levels (sodium).

Formulation

Injection (Vial)

Purpose

Broad-spectrum antibiotic for severe hospital-acquired infections, febrile neutropenia, and complicated intra-abdominal infections.

Generic Name

Piperacillin and Tazobactam Sodium

Branded Drug Names

Piperacillin + Tazobactam is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:

Scheduled Drug

Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.

Alternatives

Meropenem Cefepime

Safety Advice

Alcohol

CAUTION

Piperacillin + Tazobactam: Alcohol may worsen infection-related dehydration, dizziness, or stomach upset. Avoid or limit alcohol during antibiotic treatment.

Pregnancy

SAFE IF PRESCRIBED

Piperacillin + Tazobactam: Use during pregnancy only when prescribed for a bacterial infection; the prescriber will choose the safest suitable antibiotic.

Breast Feeding

SAFE IF PRESCRIBED

Piperacillin + Tazobactam: Many antibiotics are compatible with breastfeeding when prescribed, but monitor the infant for diarrhea, rash, or thrush.

Driving

SAFE

Piperacillin + Tazobactam: Usually does not affect driving, but dizziness, weakness, or illness symptoms can occur. Avoid driving if affected.

Liver

CAUTION

Piperacillin + Tazobactam: Use caution in liver disease or if jaundice, dark urine, or severe fatigue occurs during treatment.

Kidney

CAUTION

Piperacillin + Tazobactam: Some antibiotics require dose adjustment or monitoring in kidney disease. Use exactly as prescribed.