Palladone
Palladone is an extended-release formulation of hydromorphone hydrochloride, a highly potent Schedule II opioid agonist. It is designed for once-daily administration to manage severe chronic pain in patients who are already tolerant to opioid therapy. Note: Palladone was voluntarily withdrawn from the US market in 2005 due to the risk of rapid drug release ('dose dumping') when co-ingested with alcohol, but it remains a historically significant formulation of hydromorphone.
Dosage by Body Weight
Swallowed whole once daily. Strictly contraindicated in pediatric patients and non-opioid-tolerant patients. Must not be crushed, dissolved, or chewed. Consumption of alcohol during treatment is strictly prohibited due to fatal overdose risk.
- Body Weight
- Below 5 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not for pediatric use. Extremely high risk of fatal respiratory depression.
- Body Weight
- 5-7 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not for pediatric use. Extremely high risk of fatal respiratory depression.
- Body Weight
- 8-10 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not for pediatric use. Extremely high risk of fatal respiratory depression.
- Body Weight
- 11-15 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not for pediatric use. Extremely high risk of fatal respiratory depression.
- Body Weight
- 16-20 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not for pediatric use. Extremely high risk of fatal respiratory depression.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Contraindicated | N/A | Not for pediatric use. Extremely high risk of fatal respiratory depression. |
| 5-7 kg | Contraindicated | N/A | Not for pediatric use. Extremely high risk of fatal respiratory depression. |
| 8-10 kg | Contraindicated | N/A | Not for pediatric use. Extremely high risk of fatal respiratory depression. |
| 11-15 kg | Contraindicated | N/A | Not for pediatric use. Extremely high risk of fatal respiratory depression. |
| 16-20 kg | Contraindicated | N/A | Not for pediatric use. Extremely high risk of fatal respiratory depression. |
Formulation
Purpose
Management of persistent, moderate-to-severe pain in opioid-tolerant patients requiring continuous, around-the-clock opioid analgesia.
Generic Name
Hydromorphone HydrochlorideScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.