Oncovin
Oncovin is a brand name for vincristine sulfate, an oncology drug belonging to the class of vinca alkaloids. It works by binding to tubulin and inhibiting microtubule formation, which arrests cell division during metaphase. It is highly toxic and must be administered strictly via the intravenous route under direct supervision of a qualified oncology specialist.
Dosage by Body Weight
Dosage is highly individualized and must be determined by an oncologist. Administered strictly via intravenous infusion. FATAL IF GIVEN BY OTHER ROUTES (especially intrathecal). For pediatric patients weighing 10 kg or less, dosing is typically calculated by body weight (0.05 mg/kg once weekly) instead of body surface area (BSA).
- Body Weight
- Below 5 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- Calculated strictly by body weight for infants. Administer only under expert oncology supervision. Intravenous route only.
- Body Weight
- 5-7 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- Calculated by body weight. Monitor closely for neurotoxicity and myelosuppression.
- Body Weight
- 8-10 kg
- Dose
- 0.05 mg/kg
- Frequency
- Once weekly
- Tracking Notes
- Upper limit for weight-based pediatric dosing. Ensure precise calculation.
- Body Weight
- 11-15 kg
- Dose
- 1.5 to 2.0 mg/m²
- Frequency
- Once weekly
- Tracking Notes
- Dose must be calculated based on Body Surface Area (BSA) for children weighing over 10 kg. Typical maximum dose limit is 2 mg.
- Body Weight
- 16-20 kg
- Dose
- 1.5 to 2.0 mg/m²
- Frequency
- Once weekly
- Tracking Notes
- Dose must be calculated based on Body Surface Area (BSA). Requires continuous monitoring for adverse effects.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.05 mg/kg | Once weekly | Calculated strictly by body weight for infants. Administer only under expert oncology supervision. Intravenous route only. |
| 5-7 kg | 0.05 mg/kg | Once weekly | Calculated by body weight. Monitor closely for neurotoxicity and myelosuppression. |
| 8-10 kg | 0.05 mg/kg | Once weekly | Upper limit for weight-based pediatric dosing. Ensure precise calculation. |
| 11-15 kg | 1.5 to 2.0 mg/m² | Once weekly | Dose must be calculated based on Body Surface Area (BSA) for children weighing over 10 kg. Typical maximum dose limit is 2 mg. |
| 16-20 kg | 1.5 to 2.0 mg/m² | Once weekly | Dose must be calculated based on Body Surface Area (BSA). Requires continuous monitoring for adverse effects. |
Formulation
Purpose
Used in combination chemotherapy for the treatment of acute leukemia, Hodgkin's disease, non-Hodgkin's malignant lymphomas, rhabdomyosarcoma, neuroblastoma, and Wilms' tumor.
Generic Name
Vincristine sulfateScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.