Nevivir
Nevivir contains Nevirapine, which belongs to the class of medications known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). It works by blocking the HIV reverse transcriptase enzyme, preventing the virus from multiplying and lowering the amount of HIV in the body to help the immune system recover.
Dosage by Body Weight
Must be prescribed by a physician. In adults, it is typically started with a 14-day lead-in period of 200 mg once daily to reduce the frequency of rash, followed by a maintenance dose of 200 mg twice daily. Pediatric doses are determined by body weight or body surface area and must be strictly monitored.
- Body Weight
- Below 5 kg
- Dose
- 4 mg/kg
- Frequency
- Once daily for 14 days, then twice daily
- Tracking Notes
- Commonly given as an oral suspension. Requires highly precise syringe measurement.
- Body Weight
- 5-7 kg
- Dose
- 50 mg (5 mL oral suspension)
- Frequency
- Once daily for 14 days, then twice daily
- Tracking Notes
- Monitor closely for development of rashes or hepatic adverse effects during the first 6 weeks.
- Body Weight
- 8-10 kg
- Dose
- 80 mg (8 mL oral suspension)
- Frequency
- Once daily for 14 days, then twice daily
- Tracking Notes
- Ensure regular weight checks to adjust dosage as the child grows.
- Body Weight
- 11-15 kg
- Dose
- 100 mg (10 mL suspension or 1 pediatric tablet)
- Frequency
- Once daily for 14 days, then twice daily
- Tracking Notes
- Dispersible tablet formulations can be used if preferred and available.
- Body Weight
- 16-20 kg
- Dose
- 150 mg (15 mL suspension or 1.5 pediatric tablets)
- Frequency
- Once daily for 14 days, then twice daily
- Tracking Notes
- Do not exceed the maximum adult dosage of 200 mg twice daily.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 4 mg/kg | Once daily for 14 days, then twice daily | Commonly given as an oral suspension. Requires highly precise syringe measurement. |
| 5-7 kg | 50 mg (5 mL oral suspension) | Once daily for 14 days, then twice daily | Monitor closely for development of rashes or hepatic adverse effects during the first 6 weeks. |
| 8-10 kg | 80 mg (8 mL oral suspension) | Once daily for 14 days, then twice daily | Ensure regular weight checks to adjust dosage as the child grows. |
| 11-15 kg | 100 mg (10 mL suspension or 1 pediatric tablet) | Once daily for 14 days, then twice daily | Dispersible tablet formulations can be used if preferred and available. |
| 16-20 kg | 150 mg (15 mL suspension or 1.5 pediatric tablets) | Once daily for 14 days, then twice daily | Do not exceed the maximum adult dosage of 200 mg twice daily. |
Formulation
Purpose
Used in combination with other antiretroviral agents for the treatment of HIV-1 infection and for the prevention of mother-to-child transmission of HIV-1 in pregnant women and newborns.
Generic Name
NevirapineScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.