Mistabron
Mistabron contains Mesna, a mucolytic agent that chemically disrupts disulfide bonds in mucoproteins, thereby reducing the viscosity of bronchial secretions and facilitating expectoration. It is administered directly into the respiratory tract via nebulization or instillation.
Dosage by Body Weight
Administered via nebulizer or direct airway instillation. The usual adult dose is 3 to 6 mL (1 to 2 ampoules of 10% solution) nebulized 3 to 4 times daily. For pediatric patients, nebulization should be performed under strict medical supervision, often diluted 1:1 with sterile water or physiological saline to prevent airway irritation.
- Body Weight
- Below 5 kg
- Dose
- Not routine
- Frequency
- Use only if prescribed
- Tracking Notes
- Contraindicated or used with extreme caution in neonates. Requires specialist supervision.
- Body Weight
- 5-7 kg
- Dose
- 1.5 mL (diluted 1:1 with saline)
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Use only under direct pediatric supervision. Monitor closely for bronchospasm.
- Body Weight
- 8-10 kg
- Dose
- 1.5 mL to 3 mL (diluted 1:1 with saline)
- Frequency
- 1 to 2 times daily
- Tracking Notes
- Administer via nebulizer. Discontinue immediately if bronchospasm occurs.
- Body Weight
- 11-15 kg
- Dose
- 3 mL (1 ampoule of 10% solution)
- Frequency
- 2 times daily
- Tracking Notes
- Can be diluted with equal parts of saline to minimize airway irritation.
- Body Weight
- 16-20 kg
- Dose
- 3 mL (1 ampoule of 10% solution)
- Frequency
- 2 to 3 times daily
- Tracking Notes
- Administer via standard nebulizer. Ensure patient is hydrated.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine | Use only if prescribed | Contraindicated or used with extreme caution in neonates. Requires specialist supervision. |
| 5-7 kg | 1.5 mL (diluted 1:1 with saline) | 1 to 2 times daily | Use only under direct pediatric supervision. Monitor closely for bronchospasm. |
| 8-10 kg | 1.5 mL to 3 mL (diluted 1:1 with saline) | 1 to 2 times daily | Administer via nebulizer. Discontinue immediately if bronchospasm occurs. |
| 11-15 kg | 3 mL (1 ampoule of 10% solution) | 2 times daily | Can be diluted with equal parts of saline to minimize airway irritation. |
| 16-20 kg | 3 mL (1 ampoule of 10% solution) | 2 to 3 times daily | Administer via standard nebulizer. Ensure patient is hydrated. |
Formulation
Purpose
Mucolytic treatment to reduce the viscosity of thick, tenacious mucus in respiratory conditions such as bronchitis, bronchiectasis, cystic fibrosis, and post-operative pulmonary care.
Generic Name
MesnaScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.