Isocur
Isocur contains Isotretinoin, a systemic retinoid highly effective in treating severe recalcitrant acne. It works by suppressing sebaceous gland activity, reducing sebum production, preventing clogging of pores, and reducing local inflammation. Due to its high risk of severe birth defects (teratogenicity), its use is strictly regulated under pregnancy prevention programs.
Dosage by Body Weight
The standard daily dosage for adolescents and adults is 0.5 to 1.0 mg/kg body weight per day, administered in two divided doses with food. A typical treatment course lasts 15 to 20 weeks. This medication must only be prescribed and managed by a qualified dermatologist.
- Body Weight
- Below 5 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Isotretinoin is strictly contraindicated in infants.
- Body Weight
- 5-7 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Safety and efficacy in pediatric patients under 12 years of age have not been established.
- Body Weight
- 8-10 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not indicated for pediatric use in this weight range.
- Body Weight
- 11-15 kg
- Dose
- Contraindicated
- Frequency
- N/A
- Tracking Notes
- Not indicated for pediatric use in this weight range.
- Body Weight
- 16-20 kg
- Dose
- Not recommended
- Frequency
- N/A
- Tracking Notes
- Should only be used under extreme, rare clinical circumstances under direct supervision of a pediatric dermatologist.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Contraindicated | N/A | Isotretinoin is strictly contraindicated in infants. |
| 5-7 kg | Contraindicated | N/A | Safety and efficacy in pediatric patients under 12 years of age have not been established. |
| 8-10 kg | Contraindicated | N/A | Not indicated for pediatric use in this weight range. |
| 11-15 kg | Contraindicated | N/A | Not indicated for pediatric use in this weight range. |
| 16-20 kg | Not recommended | N/A | Should only be used under extreme, rare clinical circumstances under direct supervision of a pediatric dermatologist. |
Formulation
Purpose
Treatment of severe, resistant forms of acne (such as nodular or conglobate acne) that have not responded to other standard treatments, including systemic antibiotics and topical therapies.
Generic Name
IsotretinoinScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.