Imipenem and Cilastatin
Imipenem and Cilastatin is a combination antibiotic. Imipenem is a broad-spectrum carbapenem antibiotic that kills bacteria by inhibiting cell wall synthesis. Cilastatin is a renal dehydropeptidase inhibitor that prevents the breakdown of imipenem in the kidneys, thereby maintaining therapeutic levels of the antibiotic in the body.
Dosage by Body Weight
Typically administered via intravenous (IV) infusion or intramuscular (IM) injection. The dosage depends on the severity of the infection, susceptibility of the causative organism, and the patient's renal function and body weight. Pediatric doses are calculated based on mg/kg of body weight.
- Body Weight
- Below 5 kg
- Dose
- Not routine / 15-25 mg/kg
- Frequency
- Every 6 hours
- Tracking Notes
- Use only if prescribed. Safety and efficacy in neonates and infants weighing less than 1.5 kg or with renal impairment are not fully established.
- Body Weight
- 5-7 kg
- Dose
- 75 mg to 175 mg
- Frequency
- Every 6 hours
- Tracking Notes
- Based on a pediatric dose of 15-25 mg/kg per dose. Administered via intravenous infusion.
- Body Weight
- 8-10 kg
- Dose
- 120 mg to 250 mg
- Frequency
- Every 6 hours
- Tracking Notes
- Higher doses (up to 25 mg/kg) may be used for highly resistant infections or Pseudomonas aeruginosa.
- Body Weight
- 11-15 kg
- Dose
- 165 mg to 375 mg
- Frequency
- Every 6 hours
- Tracking Notes
- Infuse intravenously over 20 to 30 minutes for doses less than or equal to 500 mg.
- Body Weight
- 16-20 kg
- Dose
- 240 mg to 500 mg
- Frequency
- Every 6 hours
- Tracking Notes
- Maximum daily dose in pediatric patients should not exceed 2 g per day for non-cystic fibrosis infections.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / 15-25 mg/kg | Every 6 hours | Use only if prescribed. Safety and efficacy in neonates and infants weighing less than 1.5 kg or with renal impairment are not fully established. |
| 5-7 kg | 75 mg to 175 mg | Every 6 hours | Based on a pediatric dose of 15-25 mg/kg per dose. Administered via intravenous infusion. |
| 8-10 kg | 120 mg to 250 mg | Every 6 hours | Higher doses (up to 25 mg/kg) may be used for highly resistant infections or Pseudomonas aeruginosa. |
| 11-15 kg | 165 mg to 375 mg | Every 6 hours | Infuse intravenously over 20 to 30 minutes for doses less than or equal to 500 mg. |
| 16-20 kg | 240 mg to 500 mg | Every 6 hours | Maximum daily dose in pediatric patients should not exceed 2 g per day for non-cystic fibrosis infections. |
Formulation
Purpose
Used to treat severe or complicated bacterial infections, including lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections, bacterial septicemia, bone and joint infections, skin and skin structure infections, and endocarditis.
Generic Name
Imipenem and CilastatinBranded Drug Names
Imipenem and Cilastatin is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.