Fragmin
Fragmin is a low molecular weight heparin (LMWH) that acts as an anticoagulant. It works by binding to antithrombin III, accelerating its inhibition of coagulation factors Xa and IIa, thereby preventing the formation of blood clots.
Dosage by Body Weight
Fragmin must be administered by subcutaneous injection. Do not administer intramuscularly. Dosage is highly individualized based on the therapeutic indication, patient's body weight, and clinical monitoring (anti-Xa activity), particularly in pediatric patients.
- Body Weight
- Below 5 kg
- Dose
- 100 to 150 units/kg
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Pediatric dosing is highly specialized. Use only under strict specialist supervision with anti-Xa monitoring.
- Body Weight
- 5-7 kg
- Dose
- 500 to 1050 units
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Adjust dose based on target anti-Xa levels and clinical indication (treatment vs. prophylaxis).
- Body Weight
- 8-10 kg
- Dose
- 800 to 1500 units
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Monitor platelet count and check for signs of bleeding.
- Body Weight
- 11-15 kg
- Dose
- 1100 to 2250 units
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Administer subcutaneously in the abdominal wall or anterolateral thigh.
- Body Weight
- 16-20 kg
- Dose
- 1600 to 3000 units
- Frequency
- Every 12 to 24 hours
- Tracking Notes
- Dose adjustments may be necessary in patients with renal impairment.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 100 to 150 units/kg | Every 12 to 24 hours | Pediatric dosing is highly specialized. Use only under strict specialist supervision with anti-Xa monitoring. |
| 5-7 kg | 500 to 1050 units | Every 12 to 24 hours | Adjust dose based on target anti-Xa levels and clinical indication (treatment vs. prophylaxis). |
| 8-10 kg | 800 to 1500 units | Every 12 to 24 hours | Monitor platelet count and check for signs of bleeding. |
| 11-15 kg | 1100 to 2250 units | Every 12 to 24 hours | Administer subcutaneously in the abdominal wall or anterolateral thigh. |
| 16-20 kg | 1600 to 3000 units | Every 12 to 24 hours | Dose adjustments may be necessary in patients with renal impairment. |
Formulation
Purpose
Used to prevent and treat blood clots (deep vein thrombosis and pulmonary embolism), and to prevent cardiac complications in patients with unstable angina or non-Q-wave myocardial infarction.
Generic Name
Dalteparin sodiumScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.