Eptoin
Eptoin contains Phenytoin, an anticonvulsant / antiepileptic drug. It works by stabilizing neuronal membranes and limiting the spread of seizure activity in the brain by modulating sodium channels. It has a narrow therapeutic window, meaning dosing must be precise and often guided by blood level monitoring.
Dosage by Body Weight
Dosage must be highly individualized. Standard target therapeutic plasma level is 10 to 20 mcg/mL. Do not stop taking this medication abruptly, as it may precipitate status epilepticus. Take at the same time each day.
- Body Weight
- Below 5 kg
- Dose
- Not routine / Specialist determination only
- Frequency
- Use only if prescribed
- Tracking Notes
- Neonates require specialized dosing and close plasma concentration monitoring due to altered pharmacokinetics.
- Body Weight
- 5-7 kg
- Dose
- 12.5 mg to 17.5 mg total daily
- Frequency
- Divided into 2 to 3 doses daily
- Tracking Notes
- Calculated starting dose based on 5 mg/kg/day. Maintenance ranges from 4 to 8 mg/kg/day based on clinical response.
- Body Weight
- 8-10 kg
- Dose
- 20 mg to 25 mg total daily
- Frequency
- Divided into 2 to 3 doses daily
- Tracking Notes
- Calculated starting dose based on 5 mg/kg/day. Adjustments should be made slowly under medical supervision.
- Body Weight
- 11-15 kg
- Dose
- 27.5 mg to 37.5 mg total daily
- Frequency
- Divided into 2 to 3 doses daily
- Tracking Notes
- Calculated starting dose based on 5 mg/kg/day. Monitor closely for signs of toxicity (e.g., nystagmus, ataxia).
- Body Weight
- 16-20 kg
- Dose
- 40 mg to 50 mg total daily
- Frequency
- Divided into 2 to 3 doses daily
- Tracking Notes
- Calculated starting dose based on 5 mg/kg/day. Pediatric maintenance doses generally range from 4 to 8 mg/kg/day.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Not routine / Specialist determination only | Use only if prescribed | Neonates require specialized dosing and close plasma concentration monitoring due to altered pharmacokinetics. |
| 5-7 kg | 12.5 mg to 17.5 mg total daily | Divided into 2 to 3 doses daily | Calculated starting dose based on 5 mg/kg/day. Maintenance ranges from 4 to 8 mg/kg/day based on clinical response. |
| 8-10 kg | 20 mg to 25 mg total daily | Divided into 2 to 3 doses daily | Calculated starting dose based on 5 mg/kg/day. Adjustments should be made slowly under medical supervision. |
| 11-15 kg | 27.5 mg to 37.5 mg total daily | Divided into 2 to 3 doses daily | Calculated starting dose based on 5 mg/kg/day. Monitor closely for signs of toxicity (e.g., nystagmus, ataxia). |
| 16-20 kg | 40 mg to 50 mg total daily | Divided into 2 to 3 doses daily | Calculated starting dose based on 5 mg/kg/day. Pediatric maintenance doses generally range from 4 to 8 mg/kg/day. |
Formulation
Purpose
Control and prevention of generalized tonic-clonic (grand mal) seizures and complex partial (psychomotor, temporal lobe) seizures, and prevention/treatment of seizures occurring during or after neurosurgery.
Generic Name
Phenytoin SodiumScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.