Envarsus XR
Envarsus XR is an extended-release once-daily tablet formulation of tacrolimus. It is a calcineurin-inhibitor immunosuppressant designed to prevent the recipient's immune system from rejecting a newly transplanted kidney.
Dosage by Body Weight
Take once daily on an empty stomach at the same time each day, preferably in the morning. Swallow tablets whole; do not chew, divide, or crush them. Dosage must be closely monitored and individualized based on blood trough levels.
- Body Weight
- Below 5 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Tacrolimus dosing must be prescribed by a transplant specialist. Doses are calculated based on mg/kg/day and adjusted using blood level monitoring.
- Body Weight
- 5-7 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider.
- Body Weight
- 8-10 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider.
- Body Weight
- 11-15 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider.
- Body Weight
- 16-20 kg
- Dose
- Highly individualized
- Frequency
- Once daily
- Tracking Notes
- Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | Highly individualized | Once daily | Tacrolimus dosing must be prescribed by a transplant specialist. Doses are calculated based on mg/kg/day and adjusted using blood level monitoring. |
| 5-7 kg | Highly individualized | Once daily | Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider. |
| 8-10 kg | Highly individualized | Once daily | Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider. |
| 11-15 kg | Highly individualized | Once daily | Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider. |
| 16-20 kg | Highly individualized | Once daily | Requires strict titration and monitoring of whole blood trough concentrations by a healthcare provider. |
Formulation
Tablet
Purpose
Prophylaxis of organ rejection in kidney transplant patients, typically in combination with other immunosuppressants.
Generic Name
TacrolimusScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.