Briviact
Briviact (brivaracetam) is an antiepileptic drug (AED) indicated for the treatment of partial-onset seizures in patients 1 month of age and older. It works by binding with high affinity to synaptic vesicle protein 2A (SV2A) in the brain, helping to stabilize electrical activity and prevent seizures.
Dosage by Body Weight
For adults and pediatric patients weighing 50 kg or more, the recommended starting dose is 50 mg twice daily. The dose may be adjusted down to 25 mg twice daily or up to 100 mg twice daily based on clinical response and tolerability. For pediatric patients weighing less than 50 kg, the dosage is weight-based, typically administered twice daily as an oral solution.
- Body Weight
- Below 5 kg
- Dose
- 0.5 mg/kg to 1 mg/kg (starting); up to 2.5 mg/kg (maintenance)
- Frequency
- Twice daily
- Tracking Notes
- Only for infants at least 1 month of age. Dose should be calculated carefully and administered using the oral solution.
- Body Weight
- 5-7 kg
- Dose
- 2.5 mg to 7 mg (starting); up to 12.5 mg to 17.5 mg (maintenance)
- Frequency
- Twice daily
- Tracking Notes
- Based on 0.5 mg/kg to 1 mg/kg starting dose and up to 2.5 mg/kg maintenance dose.
- Body Weight
- 8-10 kg
- Dose
- 4 mg to 10 mg (starting); up to 20 mg to 25 mg (maintenance)
- Frequency
- Twice daily
- Tracking Notes
- Based on weight-based guidelines for pediatric patients. Use the provided calibrated oral dosing syringe.
- Body Weight
- 11-15 kg
- Dose
- 5.5 mg to 15 mg (starting); up to 27.5 mg to 37.5 mg (maintenance)
- Frequency
- Twice daily
- Tracking Notes
- Dose titration should be performed under close medical supervision.
- Body Weight
- 16-20 kg
- Dose
- 8 mg to 20 mg (starting); up to 40 mg to 50 mg (maintenance)
- Frequency
- Twice daily
- Tracking Notes
- For patients reaching 20 kg or more, the maximum maintenance dose guideline shifts to 2 mg/kg twice daily (maximum 100 mg twice daily).
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.5 mg/kg to 1 mg/kg (starting); up to 2.5 mg/kg (maintenance) | Twice daily | Only for infants at least 1 month of age. Dose should be calculated carefully and administered using the oral solution. |
| 5-7 kg | 2.5 mg to 7 mg (starting); up to 12.5 mg to 17.5 mg (maintenance) | Twice daily | Based on 0.5 mg/kg to 1 mg/kg starting dose and up to 2.5 mg/kg maintenance dose. |
| 8-10 kg | 4 mg to 10 mg (starting); up to 20 mg to 25 mg (maintenance) | Twice daily | Based on weight-based guidelines for pediatric patients. Use the provided calibrated oral dosing syringe. |
| 11-15 kg | 5.5 mg to 15 mg (starting); up to 27.5 mg to 37.5 mg (maintenance) | Twice daily | Dose titration should be performed under close medical supervision. |
| 16-20 kg | 8 mg to 20 mg (starting); up to 40 mg to 50 mg (maintenance) | Twice daily | For patients reaching 20 kg or more, the maximum maintenance dose guideline shifts to 2 mg/kg twice daily (maximum 100 mg twice daily). |
Formulation
Purpose
Treatment of partial-onset seizures in patients aged 1 month and older, as either monotherapy or adjunctive therapy.
Generic Name
BrivaracetamScheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.