Apresoline
Apresoline is a direct-acting peripheral vasodilator that relaxes vascular smooth muscle, primarily in arteries and arterioles, resulting in decreased peripheral vascular resistance and lowered blood pressure.
Dosage by Body Weight
Adult dosage usually starts at 10 mg four times daily, gradually increasing to 25-50 mg four times daily. Pediatric oral dosage starts at 0.75 mg/kg/day divided into 4 doses, and can be slowly titrated up if needed under medical supervision.
- Body Weight
- Below 5 kg
- Dose
- 0.5 mg to 1 mg per dose
- Frequency
- 3 to 4 times daily
- Tracking Notes
- Not routinely used in neonates. Strict clinical monitoring of blood pressure is required.
- Body Weight
- 5-7 kg
- Dose
- 1 mg to 1.5 mg per dose
- Frequency
- 3 to 4 times daily
- Tracking Notes
- Starting dose calculated at approximately 0.75 mg/kg/day. Adjust slowly over 3-4 weeks.
- Body Weight
- 8-10 kg
- Dose
- 1.5 mg to 2.5 mg per dose
- Frequency
- 3 to 4 times daily
- Tracking Notes
- Monitor closely for side effects like reflex tachycardia and headache.
- Body Weight
- 11-15 kg
- Dose
- 2 mg to 3.5 mg per dose
- Frequency
- 3 to 4 times daily
- Tracking Notes
- Ensure precise measurement of liquid formulations if tablets cannot be accurately split.
- Body Weight
- 16-20 kg
- Dose
- 3 mg to 5 mg per dose
- Frequency
- 3 to 4 times daily
- Tracking Notes
- Maximum pediatric dose should not exceed 7.5 mg/kg/day or adult equivalent limits.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 0.5 mg to 1 mg per dose | 3 to 4 times daily | Not routinely used in neonates. Strict clinical monitoring of blood pressure is required. |
| 5-7 kg | 1 mg to 1.5 mg per dose | 3 to 4 times daily | Starting dose calculated at approximately 0.75 mg/kg/day. Adjust slowly over 3-4 weeks. |
| 8-10 kg | 1.5 mg to 2.5 mg per dose | 3 to 4 times daily | Monitor closely for side effects like reflex tachycardia and headache. |
| 11-15 kg | 2 mg to 3.5 mg per dose | 3 to 4 times daily | Ensure precise measurement of liquid formulations if tablets cannot be accurately split. |
| 16-20 kg | 3 mg to 5 mg per dose | 3 to 4 times daily | Maximum pediatric dose should not exceed 7.5 mg/kg/day or adult equivalent limits. |
Formulation
Purpose
Treatment of moderate to severe essential hypertension, acute hypertensive emergency (especially in pregnancy/preeclampsia), and as an adjunctive treatment for congestive heart failure.
Generic Name
Hydralazine hydrochlorideScheduled Drug
No. This medicine is generally not treated as a scheduled/prescription-only drug in common consumer references, but local rules may vary.