Aminocaproic Acid
Aminocaproic acid is an antifibrinolytic agent that competitively inhibits plasminogen activation and, to a lesser extent, plasmin activity, thereby preventing the degradation of fibrin clots and reducing active hemorrhage.
Dosage by Body Weight
Adult oral dosage usually begins with a loading dose of 5 g, followed by 1 g to 1.25 g per hour to maintain therapeutic levels. Pediatric dosing is highly individualized and typically calculated based on body weight (approx. 100 mg/kg per dose).
- Body Weight
- Below 5 kg
- Dose
- 50 mg/kg to 100 mg/kg
- Frequency
- Every 4 to 6 hours
- Tracking Notes
- Administer only under strict specialist supervision in a hospital setting; monitor renal function.
- Body Weight
- 5-7 kg
- Dose
- 500 mg to 700 mg
- Frequency
- Every 4 to 6 hours
- Tracking Notes
- Calculated at approximately 100 mg/kg per dose. Ensure adequate hydration during therapy.
- Body Weight
- 8-10 kg
- Dose
- 800 mg to 1000 mg
- Frequency
- Every 4 to 6 hours
- Tracking Notes
- Monitor closely for signs of thrombosis or muscle weakness.
- Body Weight
- 11-15 kg
- Dose
- 1.1 g to 1.5 g
- Frequency
- Every 4 to 6 hours
- Tracking Notes
- Adjust dosage downward in patients with severe renal impairment.
- Body Weight
- 16-20 kg
- Dose
- 1.6 g to 2 g
- Frequency
- Every 4 to 6 hours
- Tracking Notes
- Total daily dose should not exceed safety limits prescribed by the physician.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| Below 5 kg | 50 mg/kg to 100 mg/kg | Every 4 to 6 hours | Administer only under strict specialist supervision in a hospital setting; monitor renal function. |
| 5-7 kg | 500 mg to 700 mg | Every 4 to 6 hours | Calculated at approximately 100 mg/kg per dose. Ensure adequate hydration during therapy. |
| 8-10 kg | 800 mg to 1000 mg | Every 4 to 6 hours | Monitor closely for signs of thrombosis or muscle weakness. |
| 11-15 kg | 1.1 g to 1.5 g | Every 4 to 6 hours | Adjust dosage downward in patients with severe renal impairment. |
| 16-20 kg | 1.6 g to 2 g | Every 4 to 6 hours | Total daily dose should not exceed safety limits prescribed by the physician. |
Formulation
Purpose
Used to treat and prevent excessive bleeding associated with systemic hyperfibrinolysis and urinary fibrinolysis.
Generic Name
Aminocaproic AcidBranded Drug Names
Aminocaproic Acid is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.