Acetylcysteine
NAC breaks disulfide bonds in mucus, making it thinner. It also restores glutathione levels in the liver during paracetamol poisoning.
Dosage by Body Weight
Mucolytic dose: 200 mg 2-3 times daily for children >6 years. Overdose protocols follow specific nomograms (Rumack-Matthew).
- Body Weight
- 15-30 kg
- Dose
- 200 mg
- Frequency
- Two to three times daily
- Tracking Notes
- For respiratory use; maintain good hydration.
| Body Weight | Dose | Frequency | Tracking Notes |
|---|---|---|---|
| 15-30 kg | 200 mg | Two to three times daily | For respiratory use; maintain good hydration. |
Formulation
Purpose
Mucolytic agent for respiratory conditions and antidote for paracetamol (acetaminophen) overdose.
Generic Name
N-Acetylcysteine (NAC)Branded Drug Names
Acetylcysteine is listed as a generic drug name. Common branded medicines that may contain the same active ingredient include:
Scheduled Drug
Yes. This medicine should be supplied or used only according to applicable prescription and regulatory requirements.
Alternatives
Safety Advice
Alcohol
CAUTIONAcetylcysteine: Alcohol increases the risk of stomach bleeding or liver-related side effects with pain relievers. Avoid or limit alcohol.
Pregnancy
SAFE IF PRESCRIBEDAcetylcysteine: Use during pregnancy only if prescribed; some pain relievers are avoided in later pregnancy.
Breast Feeding
SAFE IF PRESCRIBEDAcetylcysteine: Use while breastfeeding only as directed; many short courses are acceptable but specialist advice is needed for potent or repeated dosing.
Driving
SAFEAcetylcysteine: Usually does not affect driving, but dizziness or drowsiness can occur. Avoid driving if affected.
Liver
CAUTIONAcetylcysteine: Use caution in liver disease, especially with prolonged therapy or medicines that can affect liver enzymes.
Kidney
CAUTIONAcetylcysteine: Can worsen kidney function, especially with dehydration or long-term use. Use with medical advice in kidney disease.